Results 31 to 40 of about 554,043 (268)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier +11 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
J@ti Undip: Jurnal Teknik Industri, 2012 Sistem handling pelabuhan peti kemas merupakan masalah krusial karena berkaitan dengan waktu, biaya, dan kepuasan konsumen. Sistem handling yang baik terlihat dari waktu melakukan bongkar muat.
Dwi Indah Maryanie, Wahyudi Sutopo
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Studying the evolution of exception handling anti-patterns in a long-lived large-scale project
Journal of the Brazilian Computer Society, 2020 Exception handling is a well-known technique used to improve software robustness. However, recent studies report that developers typically neglect exception handling (mostly novice ones).
Dêmora B C de Sousa +3 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Distributed Systems for Data Handling [PDF]
, 2011 This article provides a brief historical review in the field of creation and use of distributed systems for computerized accumulation and information processing (handling) in Soviet Union, and especially in its scientific centers such as Joint Institute for Nuclear Research and not only. The author tries to demonstrate- how the chosen methods and ideas
openaire +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Expert System for Handling Congestion in Opportunistic Network
EAI Endorsed Transactions on Mobile Communications and Applications, 2018 Opportunistic networks are one of the most popular categories of mobile Adhoc networks. These types of networks usually have to deal with intermittent disconnected path from source to the destination most of the time therefor suffers from numerous key ...
Ahthasham Sajid, Khalid Hussain
doaj +1 more source