Primary Ciliary Dyskinesia: A Suggested Pathway to Transition From Pediatric to Adult Care
ABSTRACT Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous disorder characterized by motile ciliary dysfunction that impairs mucociliary clearance. Symptoms of PCD can include unexplained neonatal respiratory issues, chronic sino‐otopulmonary symptoms, recurrent infections, bronchiectasis, and subfertility.
Abel De Castro +5 more
wiley +1 more source
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma +3 more
wiley +1 more source
DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley +1 more source
Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley +1 more source
Preparing Nurse Practitioners and Physician Assistants for Effective Roles in Graduate Medical Education: A Framework for Onboarding, Role Clarity, and Patient Safety. [PDF]
Sofka S, Reece J.
europepmc +1 more source
Abstract Psychologists in primary care have the potential to deliver interventions targeting behavioural risk factors for long‐term conditions and can support self‐management of physical and mental health conditions. The British Psychological Society recommends that psychology be embedded routinely into primary care.
Kirstie McClatchey +6 more
wiley +1 more source
Understanding nursing handoff errors in clinical practice: trends and contributing factors based on a systematic review and meta-analysis. [PDF]
Yeom S, Kim MG, Park JH.
europepmc +1 more source
Diagnosis and management of neutropenia in adults: Expert guidance
Severe neutropenia can result from decreased production of neutrophil precursors in the bone marrow, as in the case of severe congenital neutropenia, or from increased utilization of neutrophils or their accelerated destruction as for drug‐induced neutropenia or autoimmune neutropenia. Severe chronic neutropenia increases susceptibility to bacterial or
Karl Welte +5 more
wiley +1 more source
Assessing Clinical Competence of Postgraduate Dental Specialty Trainees: A Scoping Review
ABSTRACT Background Assessment is essential to ensure that trainees meet competency standards in delivering patient care. However, a comprehensive summary of the literature on clinical assessment in postgraduate dental education is largely absent. Filling this gap is essential for developing effective assessment processes to help support competency ...
Fatemeh Amir‐Rad +4 more
wiley +1 more source
When More May Be Better: Reconceptualizing Clinical Handoffs in Modern Medicine. [PDF]
Berlin KE +4 more
europepmc +1 more source

