Results 41 to 50 of about 2,562,278 (292)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Classification of Handwritten Text Signatures by Person and Gender: A Comparative Study of Transfer Learning Methods

Acta Informatica Pragensia, 2022
The writing process, in which feelings and thoughts are expressed in writing, differs from person to person. Handwriting samples, which are very easy to obtain, are frequently used to identify individuals because they are biometric data.
Sidar Agduk, Emrah Aydemir
doaj   +1 more source

Handwriting recognition and identification. [PDF]

, 2021
Handwriting is one of human behavioral biometrics and handwriting recognition is a part of computer image analysis. This work covers one area of handwriting recognition writer identification, which is commonly encountered in forensics document expertise.
Karenga, Edvinas,
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Technological Support of Forensic Examination of Handwritten Material with Introduction of Neural Networks

Теория и практика судебной экспертизы
The article deals with the issues of automation and computerization of forensic handwriting examination and handwriting studies with regard to the introduction of new information technologies – the artificial neural networks – into the expert production.
K. A. Chernyshev
doaj   +1 more source

An examination of quantitative methods for Forensic Signature Analysis and the admissibility of signature verification system as legal evidence. [PDF]

, 2015
The experiments described in this thesis deal with handwriting characteristics which are involved in the production of forged and genuine signatures and complexity of signatures.
Chatzisterkotis, Thomas
core  

Periodic motor impairments in a case of 48-hour bipolar ultrarapid cycling before and under treatment with valproate [PDF]

, 2000
Motor impairments of psychiatric patients can be assessed with digital recordings of handwriting tasks. The investigation of patients with bipolar affective disorders differentiates intraindividual changes related to the patient's fluctuating affective ...
Schröter, Andreas, Tigges, Peter, Hegerl, Ulrich, Möller, Hans-Jürgen, Juckel, Georg   +4 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Automated Handwriting Analysis for Early Risk Screening of Learning Disabilities in Arabic-Speaking Children Using Convolutional Neural Networks (CNNs)

Applied Sciences
Handwriting analysis has recently emerged as a modality for the early identification of learning disabilities, as it can reveal characteristic patterns associated with motor control, spatial planning, and cognitive processing. Nevertheless, most existing
Sarah Mohammed AlMuraytib, Majid Almaraashi, Noura Alotaibi, Samer Alhassani   +3 more
doaj   +1 more source