Results 71 to 80 of about 43,210 (256)

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Longitudinal Seismic Response of Metro Tunnels Crossing a Fault with Multi-Slip Surfaces

Buildings
There are multiple seismic fault zones near Xi’an in China, among which the Li Piedmont Fault has multiple slip surfaces. A 3D finite element dynamic Soil–Fault–Tunnel model was established based on the engineering background of the Xi’an Metro tunnel ...
Qiyao Wang, Yawu Yang, Hongquan Teng, Yifei He   +3 more
doaj   +1 more source

Center Vortices, Area Law and the Catenary Solution

, 2015
We present meson-meson (Wilson loop) correlators in Z(2) center vortex models for the infrared sector of Yang-Mills theory, i.e., a hypercubic lattice model of random vortex surfaces and a continuous 2+1 dimensional model of random vortex lines.
Altarawneh, Derar, Höllwieser, Roman
core   +2 more sources

Bioinspired Adaptive Leg‐Claw Enables Robust Perching and Grasping for UAVs

Advanced Science, EarlyView.
Inspired by owl limb morphology and bat roosting behavior, this study presents a bioinspired adaptive leg‐claw mechanism that enables UAVs to perform robust and versatile perching and grasping. The design integrates a four‐link tibial structure, tension‐driven deformable feet, and active control, enabling stable perching on various branches and ...
Tianyu Cheng, Shaokun Wang, Jiehan Zou, Guiwen Shi, Zhongxue Gan, I‐Ming Chen, Guo‐Niu Zhu   +6 more
wiley   +1 more source

Subjective-guided generation of tree-like structural forms

Journal of Asian Architecture and Building Engineering
This study proposes a Monte Carlo Tree Search (MCTS)-based method for generating tree-like structures that integrates architects’ subjective judgment into structural form generation. Addressing the overreliance on automated optimization in digital design,
Peng Pei, Yi Hong, Lingchao Lei, Nan Wu
doaj   +1 more source

Mixed hp-FEM on anisotropic meshes II: Hanging nodes and tensor products of boundary layer meshes

Numerische Mathematik, 1999
Divergence stability of mixed hp-FEM for incompressible fluid flow for a general class of possibly highly irregular meshes is shown. The meshes may be refined anisotropically and contain hanging nodes on geometric patches. The inf-sup constant is independent of the aspect ratio of the elements and the dependence on the polynomial degree is given ...
Schötzau, Dominik, Schwab, Christoph, Stenberg, Rolf   +2 more
openaire   +2 more sources

All‐in‐One Underwater Quality Evaluation Metamaterial With Mechanical Robustness, Sound Attenuation, and Diffuse Reflection

Advanced Science, EarlyView.
In this work, a bioinspired all‐in‐one underwater quality evaluation metamaterial, combining sound attenuation, diffuse reflection, and mechanical robustness, is proposed based on jumping spider locomotion and human skeletal biomechanics. Meanwhile, a CNN‑driven quality evaluation framework is established for theoretically dimension‐reduced ...
Hongze Li, Zhenyu Li, Jinshui Yang, Jianhao Wu, Yidan Chen, Linzhi Wu, Hong Hu, Penglin Gao, Yegao Qu   +8 more
wiley   +1 more source

A Posteriori Error Control for the Binary Mumford-Shah Model

, 2015
The binary Mumford-Shah model is a widespread tool for image segmentation and can be considered as a basic model in shape optimization with a broad range of applications in computer vision, ranging from basic segmentation and labeling to object ...
Berkels, Benjamin, Effland, Alexander, Rumpf, Martin   +2 more
core   +1 more source

THE DESIGN IS OPTIMIZED BY WEIGHT OF THE NODE SAMPLE OF UNITS WITH COMPENSATION OF HORIZONTAL DISPLACEMENTS OF THE ATTACHMENT POINTS TO HANG THE UNIT

RUSSIAN ELECTRONIC SCIENTIFIC JOURNAL, 2020
During the machining of workpieces of parts, two negative factors act: firstly, under the action of cutting forces, elements of the technological system are deformed (machine - tooling - tool - workpiece), which leads to distortion of the geometric parameters of the finished part; secondly, under the influence of heat generated during machining, the ...
A.M.F. Al-Arabe, E.V. Markova, A.S. Boldyrev   +2 more
openaire   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source