Hemorrhagic Fever with Renal Syndrome in 4 US Soldiers, South Korea, 2005
Four US soldiers acquired hemorrhagic fever with renal syndrome while training near the Demilitarized Zone, South Korea, in 2005. Hantaan virus sequences were amplified by reverse transcription–PCR from patient serum samples and from lung tissues of ...
Jin-Won Song+10 more
doaj +1 more source
Hemorrhagic fever with renal syndrome:pathogenesis and clinical picture
Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS), which is a zoonosis endemic in eastern Asia, especially in China. The reservoir host of HTNV is field mouse (Apodemus agraricus).
Hong eJiang+4 more
doaj +1 more source
Land Use Change and Infectious Disease Emergence
Abstract Major infectious diseases threatening human health are transmitted to people from animals or by arthropod vectors such as insects. In recent decades, disease outbreaks have become more common, especially in tropical regions, including new and emerging infections that were previously undetected or unknown. Even though there is growing awareness
M. Cristina Rulli+6 more
wiley +1 more source
Evaluation and validation on cellular immunoreactivity of Hantaan virus Gc
Objective To screen, identify and verify the immunoreactive epitopes on Hantaan virus glycoprotein C-terminal (HTNV Gc). Methods On the basis of predicting the major histocompatibility complex (MHC) gene in more than 98% of the global population, the ...
XIE Mingyang+4 more
doaj +1 more source
Hantavirus-driven PD-L1/PD-L2 upregulation: An imperfect viral immune evasion mechanism [PDF]
Viruses often subvert antiviral immune responses by taking advantage of inhibitory immune signaling. We investigated if hantaviruses use this strategy.
Abdelaziz, Mohammed O.+3 more
core +2 more sources
Coumarin Derivative N6 as a Novel anti-hantavirus Infection Agent Targeting AKT
Hantaviruses are globally emerging zoonotic viruses that can cause hemorrhagic fever with renal syndrome (HFRS) in Asia and Europe, which is primarily caused by Hantaan virus (HTNV) infection, results in profound morbidity and mortality.
Zhoupeng Li+12 more
doaj +1 more source
Zoonotic virus spill over in human community has been an intensive area of viral pathogenesis and the outbreak of Hantaan virus and severe acute respiratory syndrome coronavirus 2 (SARS CoV2) after late December 2019 caused a global threat. Hantaan virus
Singh H, Kaur H, Medhi B.
europepmc +2 more sources
High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms. [PDF]
Negative-strand RNA viruses condense their genome into helical nucleocapsids that constitute essential templates for viral replication and transcription.
Arragain B+5 more
europepmc +2 more sources
Incorporation of GM-CSF or CD40L Enhances the Immunogenicity of Hantaan Virus-Like Particles [PDF]
A safe and effective Hantaan virus (HTNV) vaccine is highly desirable because HTNV causes an acute and often fatal disease (hemorrhagic fever with renal syndrome, HFRS).
Fang Wang+9 more
core +2 more sources
Innate Immunity Never “NODs” Off: NLRs Regulate the Host Anti‐Viral Immune Response
ABSTRACT A robust innate immune response is essential in combating viral pathogens. However, it is equally critical to quell overzealous immune signaling to limit collateral damage and enable inflammation resolution. Pattern recognition receptors are critical regulators of these processes.
Mackenzie K. Woolls+5 more
wiley +1 more source