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A vaccinia virus-vectored Hantaan virus vaccine protects hamsters from challenge with Hantaan and Seoul viruses but not Puumala virus

Journal of Virology, 1995
To investigate the ability of a vaccinia virus-vectored vaccine expressing the M and the S segments of Hantaan (HTN) virus (C. S. Schmaljohn, S. E. Hasty, and J. M. Dalrymple, Vaccine 10:10-13, 1992) to elicit a protective immune response against other hantaviruses, we vaccinated hamsters with the recombinant vaccine and challenged them with HTN, Seoul
Y K, Chu, G B, Jennings, C S, Schmaljohn
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Hantaan Virus Infection with Acute Renal Failure

Artificial Organs, 1995
Abstract: We report on 10 patients with acute renal involvement in Hantaan virus infection observed at the Department of Nephrology, Faculty of Medicine, Skopje, Republic of Macedonia, during a period of 3 years (October 1987‐July 1990). Eight patients were male and 2 were female, aged 37.5 ± 4.8 years.
M, Polenaković   +6 more
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Maturation of hantaan virus glycoproteins G1 and G2

Virology, 1992
Hantaan virus-infected Vero E6 cell lysates were used for immunoprecipitation with monoclonal antibodies against glycoprotein G1 (MAbG1) or G2 (MAbG2). When cell lysates were prepared with buffer containing nonionic detergent, both G1 and G2 glycoproteins were precipitated with either MAbG1 or MAbG2.
D, Antic, K E, Wright, C Y, Kang
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Coding strategy of the S genome segment of Hantaan virus

Virology, 1986
Hantaan virus is the type species of the recently recognized Hantavirus genus of Bunyaviridae. The small (S) RNA segment of the negative-sense, tripartite genome was molecularly cloned and the nucleotide sequence was determined. The RNA sequence derived from the cDNA copy was found to contain 1696 nucleotides.
C S, Schmaljohn   +3 more
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Study on the aerosol transmission of Hantaan virus

Journal of Aerosol Science, 1996
We studied some important aspects constituting aerosol transmission of Hantaan virus, including the possibility of viral aerosol generated by rodents, airborne stability, rodent’s susceptibility to aerosol challenge, and field air sampling for the virus. Our results showed that Hantaan virus aerosol could be generated through the activities of infected
Che Fengxiang   +9 more
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Ribavirin Therapy for Hantaan Virus Infection in Suckling Mice

Journal of Infectious Diseases, 1986
We recently reported that ribavirin inhibited Hantaan virus (HV) replication in vitro. In the present study, we used the HV suckling mouse model to evaluate the efficacy of treatment with various doses of ribavirin. Beginning on day 10, untreated animals, infected with ten times the amount of HV (strain 76/118) required to kill 50% of the animals, lost
J W, Huggins   +3 more
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Respiratory Hantaan Virus

1996
Hantaviruses were first recognized as a cause of serious disease in 1951 when 3000 United Nations troops in Korea developed an illness characterized by fever, headache, back and abdominal pain, with haemorrhage in many cases. This disease had a case-fatality of 5–10% and was named Korean haemorrhagic fever [18].
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Pathogenesis of experimental Hantaan virus infection in laboratory rats

Archives of Virology, 1986
Weanling Fischer rats inoculated intramuscularly with Hantaan virus (strain 76-118) developed subclinical infections characterized by transient viremia and shedding of virus in saliva, persistence of virus in lung, pancreas, spleen and liver, and development of fluorescent and neutralizing antibodies in serum with immune complex deposition in lung ...
P W, Lee   +3 more
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A Scottish case of nephropathy due to Hantaan virus infection

Journal of Infection, 1985
An illness characterised by acute renal failure, fever, conjunctivitis and a macular erythematous centrifugal rash is described in a Scot who had not recently travelled abroad. There was serological evidence that the illness was due to Hantaan or a closely related virus.
E, Walker   +3 more
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