Results 21 to 30 of about 1,691,113 (258)

Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. [PDF]

PLoS Pathogens, 2016
Segmented negative strand RNA viruses of the arena-, bunya- and orthomyxovirus families uniquely carry out viral mRNA transcription by the cap-snatching mechanism.
Juan Reguera, Piotr Gerlach, Maria Rosenthal, Stephanie Gaudon, Francesca Coscia, Stephan Günther, Stephen Cusack   +6 more
doaj   +4 more sources

Insight into the Hantaan virus RNA-dependent RNA polymerase inhibition using in-silico approaches. [PDF]

Mol Divers, 2023
The Hantaan virus (HTN) is a member of the hantaviridae family. It is a segmented type, negative-strand virus (sNSVs). It causes hemorrhagic fever with renal syndrome, which includes fever, vascular hemorrhage, and renal failure.
Faisal S, Badshah SL, Badshah SL, Sharaf M, Abdalla M.   +4 more
europepmc   +2 more sources

IL-15 induced bystander activation of CD8⁺ T cells may mediate endothelium injury through NKG2D in Hantaan virus infection. [PDF]

Front Cell Infect Microbiol, 2022
Introduction Hantaan virus (HTNV) can cause endothelium injury in hemorrhagic fever with renal syndrome (HFRS) patients. Bystander activation of CD8+ T cells by virus infection has been shown that was involved in host injury, but it is unclear during ...
Zhang X, Zhang Y, Liu H, Tang K, Zhang C, Wang M, Xue M, Jia X, Hu H, Li N, Zhuang R, Jin B, Zhang F, Zhang Y, Ma Y.   +14 more
europepmc   +2 more sources

Comparative Immunoreactivity Analyses of Hantaan Virus Glycoprotein-Derived MHC-I Epitopes in Vaccination. [PDF]

Vaccines (Basel), 2022
MHC-I antigen processes and presentation trigger host-specific anti-viral cellular responses during infection, in which epitope-recognizing cytotoxic T lymphocytes eliminate infected cells and contribute to viral clearance through a cytolytic killing ...
Sun B, Zhang J, Wang J, Liu Y, Sun H, Lu Z, Chen L, Ding X, Pan J, Hu C, Yang S, Jiang D, Yang K.   +12 more
europepmc   +2 more sources

Hyperamylasemia Caused by the Hantaan Virus: A Retrospective Study of 101 Patients with Hemorrhagic Fever with Renal Syndrome in West China. [PDF]

Biomed Res Int, 2022
Background Hyperamylasemia (HA) is an inconspicuous manifestation of hemorrhagic fever with renal syndrome (HFRS) in Baoji city, West China. Hantaan virus (HTNV) is the only pathogen-caused HFRS in this region, but the knowledge about HA in the local ...
Zhang S, Shi L, Jiang X, Yang X, Wu L, Wang C, Jing F, Chen T.   +7 more
europepmc   +2 more sources

Single dose recombinant VSV based vaccine elicits robust and durable neutralizing antibody against Hantaan virus. [PDF]

NPJ Vaccines
Hantaan virus (HTNV) is a pathogenic orthohantavirus prevalent in East Asia that is known to cause hemorrhagic fever with severe renal syndrome (HFRS), which has a high fatality rate.
Zhang H, Liu H, Wei J, Dang Y, Wang Y, Yang Q, Zhang L, Ye C, Wang B, Jin X, Cheng L, Ma H, Dong Y, Li Y, Bai Y, Lv X, Lei Y, Xu Z, Ye W, Zhang F.   +19 more
europepmc   +2 more sources

Serum superoxide dismutase level is a potential biomarker of disease prognosis in patients with hemorrhagic fever with renal syndrome caused by the Hantaan virus. [PDF]

BMC Infect Dis, 2022
Background Hemorrhagic fever with renal syndrome (HFRS) is a disease with increased systemic inflammation and a high fatality rate. Oxidative stress is crucial for inflammation in the pathogeneses of various diseases.
Tian Z, Yao N, Wu Y, Wang F, Zhao Y.
europepmc   +2 more sources

Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers

Nature Communications
Hantaan virus is a dangerous human pathogen whose segmented negative-stranded RNA genome is replicated and transcribed by a virally-encoded multi-functional polymerase.
Quentin Durieux Trouilleton, Dominique Housset, Paco Tarillon, Benoît Arragain, Hélène Malet   +4 more
doaj   +2 more sources

RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection. [PDF]

Front Cell Infect Microbiol, 2020
Hantaan virus (HTNV), a Hantavirus serotype that is prevalent in Asia, causes hemorrhagic fever with renal syndrome (HFRS) with high mortality in human race. However, the pathogenesis of HTNV infection remains elusive.
Lu S, Zhu N, Guo W, Wang X, Li K, Yan J, Jiang C, Han S, Xiang H, Wu X, Liu Y, Xiong H, Chen L, Gong Z, Luo F, Hou W.   +15 more
europepmc   +2 more sources

Genetic diversity and evolution of Hantaan virus in China and its neighbors. [PDF]

PLoS Negl Trop Dis, 2020
Backgroud Hantaan virus (HTNV), as one of the pathogenic hantaviruses of HFRS, has raised serious concerns in Eurasia. China and its neighbors, especially Russia and South Korea, are seriously suffered HTNV infections.
Li N, Li A, Liu Y, Wu W, Li C, Yu D, Zhu Y, Li J, Li D, Wang S, Liang M.   +10 more
europepmc   +2 more sources