Results 11 to 20 of about 290,368 (328)

Detecting Local Haplotype Sharing and Haplotype Association [PDF]

Genetics, 2014
Abstract A novel haplotype association method is presented, and its power is demonstrated. Relying on a statistical model for linkage disequilibrium (LD), the method first infers ancestral haplotypes and their loadings at each marker for each individual.
Yongtao Guan, Hanli Xu, Hanli Xu
openaire   +3 more sources

A Common Variant Associated with Dyslexia Reduces Expression of the KIAA0319 Gene [PDF]

, 2009
Numerous genetic association studies have implicated the KIAA0319 gene on human chromosome 6p22 in dyslexia susceptibility. The causative variant(s) remains unknown but may modulate gene expression, given that (1) a dyslexia-associated haplotype has been
Megan Y. Dennis, Silvia Paracchini, Thomas S. Scerri, Ludmila Prokunina-Olsson, Julian C. Knight, Richard Wade-Martins, Penny Coggill, Stephan Beck, Eric D. Green, Anthony P. Monaco, Lisa Stubbs, SE Fisher, SE Shaywitz, SE Shaywitz, JC DeFries, JC DeFries, JM Finucci, JW Gilger, JC DeFries, M Taipale, TS Scerri, KG Wigg, K Hannula-Jouppi, H Meng, J Schumacher, C Francks, N Cope, D Harold, M Luciano, S Paracchini, H Anthoni, AM Galaburda, GD Rosen, SW Threlkeld, Y Wang, TJ Burbridge, S Paracchini, AM Galaburda, AJ Marlow, SE Fisher, GR Abecasis, JC Barrett, S Schwartz, NG Copeland, S Warming, GH Perdew, DC King, J Taylor, JW Thomas, A Visel, WJ Kent, AE Kel, R Kageyama, PI Lin, S Paracchini, JA Fiez, P Swoboda, R Dubruille, M Gotz, KY Chau, JD Klemm, RA Sturm, T Kiyota, MK Kim, J Bode, E Birney, JC Knight, T Pastinen   +67 more
core   +7 more sources

Haplotype reconstruction error as a classical misclassification problem [PDF]

, 2008
Statistically reconstructing haplotypes from single nucleotide polymorphism (SNP) genotypes, can lead to falsely classified haplotypes. This can be an issue when interpreting haplotype association results or when selecting subjects with certain ...
Bongardt, Friedhelm, Heid, Iris M., Küchenhoff, Helmut, Lamina, Claudia   +3 more
core   +1 more source

Joint Haplotype Assembly and Genotype Calling via Sequential Monte Carlo Algorithm [PDF]

, 2015
Genetic variations predispose individuals to hereditary diseases, play important role in the development of complex diseases, and impact drug metabolism. The full information about the DNA variations in the genome of an individual is given by haplotypes,
Ahn, Soyeon, Vikalo, Haris
core   +3 more sources

Association of FCGR3A and FCGR3B haplotypes with rheumatoid arthritis and primary Sjögren's syndrome [POSTER PRESENTATION] [PDF]

, 2005
Background Rheumatoid arthritis (RA) is an autoimmune disease that is thought to arise from a complex interaction between multiple genetic factors and environmental triggers.
Barrett, J.H., Bowman, S.J., Conaghan, P.G., Cooper, D., Emery, P., Green, M., Haroon-Rashid, L., Isaacs, J.D., Lawson, C.A., Mackie, S., Martin, S., Morgan, A.W., Pease, C.T., Quinn, M., Robinson, J.I.   +14 more
core   +2 more sources

Minimal haplotype tagging [PDF]

Proceedings of the National Academy of Sciences, 2003
The high frequency of single-nucleotide polymorphisms (SNPs) in the human genome presents an unparalleled opportunity to track down the genetic basis of common diseases. At the same time, the sheer number of SNPs also makes unfeasible genomewide disease association studies.
Isaac S. Kohane, Ross Lazarus, Scott T. Weiss, Marco F. Ramoni, Louis M. Kunkel, Paola Sebastiani   +5 more
openaire   +4 more sources

Search for Risk Haplotype Segments with GWAS Data by Use of Finite Mixture Models [PDF]

, 2015
The region-based association analysis has been proposed to capture the collective behavior of sets of variants by testing the association of each set instead of individual variants with the disease.
Ali, Fadhaa, Zhang, Jian
core   +1 more source

Experimental Infection of Different Tomato Genotypes with Tomato mosaic virus Led to a Low Viral Population Heterogeneity in the Capsid Protein Encoding Region

The Plant Pathology Journal, 2017
The complete genome sequence of a Slovak SL-1 isolate of Tomato mosaic virus (ToMV) was determined from the next generation sequencing (NGS) data, further confirming a limited sequence divergence in this tobamovirus species.
Nina Sihelská, Zuzana Vozárová, Lukáš Predajňa, Katarína Šoltys, Martina Hudcovicová, Daniel Mihálik, Ján Kraic, Michaela Mrkvová, Otakar Kúdela, Miroslav Glasa   +9 more
doaj   +1 more source

Computational analyses of ancient pathogen DNA from herbarium samples: challenges and prospects

Frontiers in Plant Science, 2015
The application of DNA sequencing technology to the study of ancient DNA has enabled the reconstruction of past epidemics from genomes of historically important plant-associated microbes.
Kentaro eYoshida, Kentaro eYoshida, Eriko eSasaki, Sophien eKamoun   +3 more
doaj   +1 more source

HandyCNV: Standardized Summary, Annotation, Comparison, and Visualization of Copy Number Variant, Copy Number Variation Region, and Runs of Homozygosity

Frontiers in Genetics, 2021
Detection of CNVs (copy number variants) and ROH (runs of homozygosity) from SNP (single nucleotide polymorphism) genotyping data is often required in genomic studies.
Jinghang Zhou, Jinghang Zhou, Liyuan Liu, Liyuan Liu, Thomas J. Lopdell, Dorian J. Garrick, Yuangang Shi   +6 more
doaj   +1 more source