Detecting Local Haplotype Sharing and Haplotype Association [PDF]
Genetics, 2014 Abstract A novel haplotype association method is presented, and its power is demonstrated. Relying on a statistical model for linkage disequilibrium (LD), the method first infers ancestral haplotypes and their loadings at each marker for each individual.
Yongtao Guan, Hanli Xu, Hanli Xu
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Joint Haplotype Assembly and Genotype Calling via Sequential Monte Carlo Algorithm [PDF]
, 2015 Genetic variations predispose individuals to hereditary diseases, play important role in the development of complex diseases, and impact drug metabolism. The full information about the DNA variations in the genome of an individual is given by haplotypes,
Ahn, Soyeon, Vikalo, Haris
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Exploring effective approaches for haplotype block phasing
BMC Bioinformatics, 2019 Background Knowledge of phase, the specific allele sequence on each copy of homologous chromosomes, is increasingly recognized as critical for detecting certain classes of disease-associated mutations. One approach for detecting such mutations is through
Ziad Al Bkhetan +4 more
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Minimal haplotype tagging [PDF]
Proceedings of the National Academy of Sciences, 2003 The high frequency of single-nucleotide polymorphisms (SNPs) in the human genome presents an unparalleled opportunity to track down the genetic basis of common diseases. At the same time, the sheer number of SNPs also makes unfeasible genomewide disease association studies.
Isaac S. Kohane +5 more
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Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution Genome evolution and evolutionary systems biology [PDF]
, 2014 © 2014 Janha et al.; licensee BioMed Central Ltd.Background: Cytochrome P450 CYP2C19 metabolizes a wide range of pharmacologically active substances and a relatively small number of naturally occurring environmental toxins.
Janha, RE +5 more
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Minimum error correction-based haplotype assembly: considerations for long read data
, 2020 The single nucleotide polymorphism (SNP) is the most widely studied type of genetic variation. A haplotype is defined as the sequence of alleles at SNP sites on each haploid chromosome.
de Ridder, Dick +2 more
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The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients [PDF]
, 2008 We investigated the relationships between functional genetic variants of the 5-HT(2C) receptor and multidrug-resistant protein (MDR1), coding for P-glycoprotein, and second generation antipsychotic (SDA)-induced weight gain among 108 female schizophrenic
Bilušić, Hrvoje +5 more
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A simple PCR-RFLP method for genetic phase determination in compound heterozygotes
Frontiers in Genetics, 2012 When susceptibility to diseases is caused by cis-effects of multiple alleles at adjacent polymorphic sites, it may be difficult to assess with confidence the genetic phase and identify individuals carrying the risk haplotype.
Rodney T Perry +2 more
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Contracaecum sp. larvae (Nematoda: Anisakidae) parasitizing Astyanax lacustris (Lütken, 1875) (Characiformes, Characidae) and Geophagus brasiliensis (Quoy & Gaimard, 1824) (Cichliformes, Cichlidae) in the Pardo River, São Paulo State, southeast Brazil [PDF]
Brazilian Journal of BiologyAstyanax lacustris (n = 26) and Geophagus brasiliensis (n = 28) were collected from two sampling sites along the Pardo River, in Botucatu, São Paulo, Brazil, and examined for parasites.
H. L. Rocha +5 more
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Insects, 2020 Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) is an invasive alien species and a key agricultural pest. Its native parasitoids (Trissolcus japonicus Ashmead and Tr. mitsukurii Ashmead) have been registered in several countries where H. halys brought
Livia Zapponi +5 more
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