Results 21 to 30 of about 209,468 (302)

Genetic association mapping via evolution-based clustering of haplotypes. [PDF]

, 2007
Multilocus analysis of single nucleotide polymorphism haplotypes is a promising approach to dissecting the genetic basis of complex diseases. We propose a coalescent-based model for association mapping that potentially increases the power to detect ...
Ioanna Tachmazidou, Maria De Iorio, Claudio J. Verzilli, De Iorio, Maria, De Iorio, M, Claudio J Verzilli, Verzilli, Claudio J, Tachmazidou, I, Tachmazidou, Ioanna, Verzilli, CJ   +9 more
core   +2 more sources

A genome-wide combinatorial strategy dissects complex genetic architecture of seed coat colour in chickpea

Frontiers in Plant Science, 2015
The study identified 9045 high-quality SNPs employing both genome-wide GBS- and candidate gene-based SNP genotyping assays in 172, including 93 cultivated (desi and kabuli) and 79 wild chickpea accessions.
Deepak eBajaj, Shouvik eDas, Hari Deo eUpadhyaya, Rajeev eRanjan, Rajeev eRanjan, SAURABH eBADONI, Vinod eKumar, Shailesh eTripathi, CL Laxmipathi Gowda, Shivali eSharma, Sube eSingh, Akhilesh eTyagi, SWARUP KUMAR PARIDA   +12 more
doaj   +1 more source

Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history [PDF]

, 2006
The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer susceptibility to disease requires greater knowledge of ...
John Trowsdale, Wilming, LG, Roberts Anne N, Coggill, P, Laurens G Wilming, Sarah Sims, Trowsdale, J, Atrazhev Alexey M, Palmer, S, Beck Stephan, Todd John A, Jane Rogers, Sawcer, S, Coggill Penny, Ashurst Jennifer L, Trowsdale John, Almeida Jeff, Alexey M Atrazhev, Elliott John F, Beck, S, Sophie Palmer, Hurles Matthew E, Traherne James A, Roberts, AN, Miretti, M, Stewart, CA, de Jong, PJ, Pieter J de Jong, Stephen Sawcer, Hurles, ME, James A Traherne, C Andrew Stewart, de Jong Pieter J., Matthew E Hurles, Horton, R, Penny Coggill, Jennifer L Ashurst, Sims, S, Horton Roger, Stewart C. Andrew, Almeida, J, Ashurst, JL, Carrington Mary, Elliott, JF, C. Andrew Stewart, Stephan Beck, Rogers Jane, Palmer Sophie, Pieter J. de Jong, Carrington, M, Rogers, J, Atrazhev, AM, Roger Horton, Sawcer Stephen, Traherne, JA, Jeff Almeida, Sims Sarah, John A Todd, Marcos M Miretti, Anne N Roberts, Wilming Laurens G, Todd, JA, Mary Carrington, Miretti Marcos M, John F Elliott   +64 more
core   +1 more source

HandyCNV: Standardized Summary, Annotation, Comparison, and Visualization of Copy Number Variant, Copy Number Variation Region, and Runs of Homozygosity

Frontiers in Genetics, 2021
Detection of CNVs (copy number variants) and ROH (runs of homozygosity) from SNP (single nucleotide polymorphism) genotyping data is often required in genomic studies.
Jinghang Zhou, Jinghang Zhou, Liyuan Liu, Liyuan Liu, Thomas J. Lopdell, Dorian J. Garrick, Yuangang Shi   +6 more
doaj   +1 more source

Family-Based Haplotype Estimation and Allele Dosage Correction for Polyploids Using Short Sequence Reads

Frontiers in Genetics, 2019
DNA sequence reads contain information about the genomic variants located on a single chromosome. By extracting and extending this information using the overlaps between the reads, the haplotypes of an individual can be obtained.
Ehsan Motazedi, Ehsan Motazedi, Chris Maliepaard, Richard Finkers, Richard Visser, Dick de Ridder   +5 more
doaj   +1 more source

Efficient Sequencing, Assembly, and Annotation of Human KIR Haplotypes

Frontiers in Immunology, 2020
The homology, recombination, variation, and repetitive elements in the natural killer-cell immunoglobulin-like receptor (KIR) region has made full haplotype DNA interpretation impossible in a high-throughput workflow.
David Roe, Jonathan Williams, Keyton Ivery, Jenny Brouckaert, Nick Downey, Chad Locklear, Rui Kuang, Rui Kuang, Martin Maiers   +8 more
doaj   +1 more source

Plotting haplotype-specific linkage disequilibrium patterns by extended haplotype homozygosity [PDF]

, 2003
Summary: Association studies may request more details of a specific haplotype. Haplotype-specific decay of linkage disequilibrium is such a crucial and versatile characteristic. It may be used, e.g.
J. C. Mueller, C. Andreoli, Andreoli, C., Mueller, J., Müller, J.C.   +4 more
core   +1 more source

phylogenetic study of the Mongolian Tree Pipit (Anthus trivialis, Linnaeus, 1758) population based on mitochondrial DNA (mtDNA) genes

Proceedings of the Mongolian Academy of Sciences
Our aim was to identify nucleotide polymorphisms, assess their distribution in haplotype diversity, and construct a phylogenetic tree by analyzing mtDNA markers of the Mongolian Tree Pipits(Anthus trivialis).
Ulziisaikhan Tumendemberel, Sod-erdene Byambadash, Gabor Sramko, Tserendulam Batsukh   +3 more
doaj   +1 more source

Chromosome 9 ALS and FTD locus is probably derived from a single founder. [PDF]

, 2012
We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations.
Rollinson, PS, DeJesus-Hernandez, M, Pentti J. Tienari, Hardy, J, Morrison, Karen E., Aleksey Shatunov, John C. van Swieten, Rademakers, R, Restagno, Gabriella, Bryan J. Traynor, Rollinson, Pamela Sara, Karen E. Morrison, Ian R. Mackenzie, Morris, Huw Rees, Traynor, BJ, Mariely DeJesus-Hernandez, Morrison, KE, Pamela Sara Rollinson, Mackenzie, Ian R., Simón-Sánchez, J, Nalls, MA, van Swieten, J.C., Waite, Adrian, Javier Simón-Sánchez, Boeve, Bradley F., Morrison, Karen, Nalls, Michael A., Restagno, G, Myllykangas, L, Boxer, Adam L., Waite, Adrian James, Ammar Al-Chalabi, Waite, A, Mora, G, Heutink, P, Boeve, BF, Traynor, Bryan J., Adam L. Boxer, Shatunov, Aleksey, Rosa Rademakers, DeJesus-Hernandez, Mariely, Mackenzie, IR, Nigel Williams, Pickering-Brown, S, Hannu Laaksovirta, Chiò, A, Williams, N, Simón-Sánchez, Javier, Laaksovirta, Hannu, Mok, K, Laaksovirta, H, Adrian Waite, Shaw, Pamela J., Pickering-Brown, Stuart, Rademakers, Rosa, Heutink, Peter, van Swieten, JC, Tienari, PJ, Liisa Myllykangas, Peuralinna, T, Morris, HR, Hardy, John, Schymick, J, Shatunov, A, John Hardy, Huw R. Morris, Gabriele Mora, Peuralinna, Terhi, Chio', Adriano, Peter Heutink, Richard W. Orrell, Terhi Peuralinna, Morrison, Karen E.; id_orcid, Myllykangas, Liisa, Williams, Nigel, Bradley F. Boeve, Gabriella Restagno, Pamela J. Shaw, Orrell, RW, Shatunov, Aleksey; id_orcid, Kin Mok, Al-Chalabi, Ammar, Boxer, AL, Mok, Kin, Mora, Gabriele, Orrell, Richard W., Tienari, Pentti J., Adriano Chiò, Schymick, Jennifer, Morris, Huw R., Shaw, PJ, Williams, Nigel Melville, Al-Chalabi, A, Chiò, Adriano, van Swieten, John C., Michael A. Nalls, Stuart Pickering-Brown, Jennifer Schymick   +97 more
core   +1 more source

Clinical and Metabolic Signatures of FAM47E–SHROOM3 Haplotypes in a General Population Sample

Kidney International Reports
Introduction: Genome-wide association studies (GWAS) identified a locus on chromosome 4q21.1, spanning the Family With Sequence Similarity 47 Member E (FAM47E), Starch Binding Domain 1 (STBD1), Coiled-Coil Domain Containing 158 (CCDC158), and Shroom ...
Dariush Ghasemi-Semeskandeh, Eva König, Luisa Foco, Nikola Dordevic, Martin Gögele, Johannes Rainer, Markus Ralser, Dianne Acoba, Francisco S. Domingues, Dorien J.M. Peters, Peter P. Pramstaller, Cristian Pattaro   +11 more
doaj   +1 more source