Results 21 to 30 of about 290,368 (328)

Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B [PDF]

, 2005
The Fcγ receptors play important roles in the initiation and regulation of many immunological and inflammatory processes, and genetic variants (FCGR) have been associated with numerous autoimmune and infectious diseases. The data in rheumatoid arthritis (
Ali, Manir, Barrett , Jennifer H., Boylston, Arthur W., Deva Situnayake, R, Emery, Paul, Griffiths, Bridget, Isaacs, John D., Jones, E. A. (Elizabeth A.), Keyte, Viki H., Markham, Alexander F, Morgan, Ann W., Old, R. W., Ponchel, Frederique, Robinson, Jim I., Subramanian, Deepak   +14 more
core   +3 more sources

Long-range, high-throughput haplotype determination via haplotype-fusion PCR and ligation haplotyping [PDF]

Nucleic Acids Research, 2008
Ligation Haplotyping is a robust, novel method for experimental determination of haplotypes over long distances, which can be applied to assaying both sequence and structural variation. The simplicity and efficacy of the method for genotyping large chromosomal rearrangements and haplotyping SNPs over long distances make it a valuable and powerful ...
Daniel J. Turner, Matthew E. Hurles, Chris Tyler-Smith   +2 more
openaire   +3 more sources

Prediction of haplotypes for ungenotyped animals and its effect on marker-assisted breeding value estimation [PDF]

, 2010
Background: In livestock populations, missing genotypes on a large proportion of animals are a major problem to implement the estimation of marker-assisted breeding values using haplotypes.
Calus, M.P.L., Mulder, H.A., Veerkamp, R.F.   +2 more
core   +3 more sources

Family-Based Haplotype Estimation and Allele Dosage Correction for Polyploids Using Short Sequence Reads

Frontiers in Genetics, 2019
DNA sequence reads contain information about the genomic variants located on a single chromosome. By extracting and extending this information using the overlaps between the reads, the haplotypes of an individual can be obtained.
Ehsan Motazedi, Ehsan Motazedi, Chris Maliepaard, Richard Finkers, Richard Visser, Dick de Ridder   +5 more
doaj   +1 more source

Analysis of the mtDNA D-loop Region Casts New Light on Philippine Red Junglefowl Phylogeny and Relationships to Other Junglefowl Species in Asia

The Journal of Poultry Science, 2022
Red junglefowl (RJF) is considered the ancestor of domestic chickens. However, the possible maternal origin, genetic diversity, and subspecies classification of the Philippine (PH) RJF remains uncertain.
Jade Dhapnee Z. Compendio, Jam Marrie Nanche P. Mantana, Masahide Nishibori   +2 more
doaj   +1 more source

Mitochondrial and Y chromosome haplotype motifs as diagnostic markers of Jewish ancestry: a reconsideration.

Frontiers in Genetics, 2014
Several authors have proposed haplotype motifs based on site variants at the mitochondrial genome (mtDNA) and the non-recombining portion of the Y chromosome (NRY) to trace the genealogies of Jewish people.
Sergio eTofanelli, Luca eTaglioli, Stefania eBertoncini, Paolo eFrancalacci, Anatole eKlyosov, Luca ePagani, Luca ePagani   +6 more
doaj   +1 more source

Genome-wide identification, expression pattern and genetic variation analysis of SWEET gene family in barley reveal the artificial selection of HvSWEET1a during domestication and improvement

Frontiers in Plant Science, 2023
SWEET (Sugars Will Eventually be Exported Transporter) proteins, an essential class of sugar transporters, are involved in vital biological processes of plant growth and development.
Wenhao Yue, Wenhao Yue, Kangfeng Cai, Kangfeng Cai, Xue Xia, Xue Xia, Xue Xia, Lei Liu, Lei Liu, Junmei Wang, Junmei Wang   +10 more
doaj   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley

The Saudi Journal of Gastroenterology, 2014
Background/Aim: Phospholipase C epsilon 1 (PLCE1) plays a crucial role in carcinogenesis and progression of several types of cancers. A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus.
Manzoor A Malik, Priya Srivastava, Showkat A Zargar, Balraj Mittal   +3 more
doaj   +1 more source

Non-coding and intergenic genetic variants of human arylamine N-acetyltransferase 2 (NAT2) gene are associated with differential plasma lipid and cholesterol levels and cardiometabolic disorders

Frontiers in Pharmacology, 2023
Arylamine N-acetyltransferase 2 (NAT2) is a phase II metabolic enzyme, best known for metabolism of aromatic amines and hydrazines. Genetic variants occurring in the NAT2 coding region have been well-defined and are known to affect the enzyme activity or
Kyung U. Hong, Kennedy M. Walls, David W. Hein   +2 more
doaj   +1 more source