Results 61 to 70 of about 133,224 (273)

Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 110-121, January 2023., 2023
Abstract Indomethacin is used commonly in preterm neonates for the prevention of intracranial hemorrhage and closure of an abnormally open cardiac vessel. Due to biomedical advances, the infants who receive this drug in the neonatal intensive care unit setting have become younger, smaller, and less mature (more preterm) at the time of treatment.
Wojciech Krzyzanski   +7 more
wiley   +1 more source

A systematic review and evaluation of statistical methods for group variable selection

open access: yesStatistics in Medicine, Volume 42, Issue 3, Page 331-352, 10 February 2023., 2023
This review condenses the knowledge on variable selection methods implemented in R and appropriate for datasets with grouped features. The focus is on regularized regressions identified through a systematic review of the literature, following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines.
Gregor Buch   +4 more
wiley   +1 more source

GenHap: A Novel Computational Method Based on Genetic Algorithms for Haplotype Assembly [PDF]

open access: yesarXiv, 2018
The computational problem of inferring the full haplotype of a cell starting from read sequencing data is known as haplotype assembly, and consists in assigning all heterozygous Single Nucleotide Polymorphisms (SNPs) to exactly one of the two chromosomes.
arxiv  

Population genomic analysis of the Speckled Dace species complex identifies three distinct lineages in California

open access: yesTransactions of the American Fisheries Society, Volume 151, Issue 6, Page 695-710, November 2022., 2022
Abstract Objective Speckled Dace Rhinichthys osculus is small cyprinoid fish that is widespread in western North America. In California and elsewhere it is currently treated as a single species with multiple subspecies, many undescribed. However, these subspecies may represent evolutionary lineages that are cryptic species because they cannot be ...
Yingxin Su   +6 more
wiley   +1 more source

Genome‐wide marker effect heterogeneity is associated with a large effect dormancy locus in winter malting barley

open access: yesThe Plant Genome, Volume 15, Issue 4, December 2022., 2022
Abstract Prediction of trait values in plant breeding populations typically relies on assumptions about marker effect homogeneity across populations. Evidence is presented for winter malting barley (Hordeum vulgare L.) germination traits that a single, causative, large‐effect gene in the Seed dormancy 1 region on Chromosome 5H, HvAlaAT1 (Qsd1), leads ...
Travis E. Rooney   +2 more
wiley   +1 more source

Convergence of Y chromosome STR haplotypes from different SNP haplogroups compromises accuracy of haplogroup prediction [PDF]

open access: yesarXiv, 2013
Short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) are two kinds of commonly used markers in Y chromosome studies of forensic and population genetics. There has been increasing interest in the cost saving strategy by using the STR haplotypes to predict SNP haplogroups.
arxiv  

Genomic Evaluation of Recombination in Small Highly Inbred Beef Cattle Populations

open access: yesAnimal Research and One Health, EarlyView.
The study characterizes recombination in small beef cattle populations, revealing higher rates in CGC composites compared to inbred Line 1 Herefords. It identifies significant SNP associations linked to recombination across various autosomes, highlighting complex polygenic influences, with implications for genetic diversity and breeding strategies ...
E. Hay, A. S. Ling
wiley   +1 more source

Sparse kernel models provide optimization of training set design for genomic prediction in multiyear wheat breeding data

open access: yesThe Plant Genome, Volume 15, Issue 4, December 2022., 2022
Abstract The success of genomic selection (GS) in breeding schemes relies on its ability to provide accurate predictions of unobserved lines at early stages. Multigeneration data provides opportunities to increase the training data size and thus, the likelihood of extracting useful information from ancestors to improve prediction accuracy.
Marco Lopez‐Cruz   +12 more
wiley   +1 more source

Shennong 1 Chicken 40K Liquid Chip: Advancing Genetic Research in Chinese Indigenous Chickens

open access: yesAnimal Research and One Health, EarlyView.
Based on comprehensive genomic data of Chinese indigenous chickens, we developed a specialized genotyping array for this population. Comparative analyses with published mainstream arrays and evaluations, including genetic assessment of diverse chicken types and gene mining analyses, demonstrated its superior applicability to Chinese indigenous chickens.
Chaoqun Gao   +14 more
wiley   +1 more source

Imputation of low‐density marker chip data in plant breeding: Evaluation of methods based on sugar beet

open access: yesThe Plant Genome, Volume 15, Issue 4, December 2022., 2022
Abstract Low‐density genotyping followed by imputation reduces genotyping costs while still providing high‐density marker information. An increased marker density has the potential to improve the outcome of all applications that are based on genomic data.
Tobias Niehoff   +3 more
wiley   +1 more source

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