Results 81 to 90 of about 209,468 (302)

Genomic Structural Variations Provide Insights Into Litter Size and Teat Number Traits in Hu Sheep

open access: yesAnimal Research and One Health, EarlyView.
Here, we conducted whole genome sequencing on 300 Hu sheep with an average depth of 16.51X. Two candidate genes associated with litter size and teat number traits were identified, namely MAST2 and AFDN. ABSTRACT Litter size and the teat number are important economic indicators in sheep production.
Xin Xiang   +3 more
wiley   +1 more source

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez   +295 more
wiley   +1 more source

Haplotype network for Nassau grouper.

open access: yes, 2014
Circles are sized proportionally to the number of individuals that possess each haplotype. The pie chart within each haplotype represents the relative frequency of individuals from each color-coded region.
Brice X. Semmens (183075)   +11 more
core   +1 more source

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton   +8 more
wiley   +1 more source

Determination of linkage disequilibrium region suggests association of the ancient haplotype, hX with neural function [PDF]

open access: yes, 2011
Modern human populations are known to contain "ancient haplotypes" that originated from archaic humans by hybridization. Some of them had been reported before the development of human genomic diversity databases, such as HapMap. Consequently,
Tsutomu Kanasashi, Makoto Shimada
core  

Haplotype association analysis.

open access: yes, 2013
Haplotype association analysis illustrating z-Normalized AFQT scores among different genotype carriers pre-injury, Phase II and Phase III. Haplotype 6 SNPs (A) include all the SNPs in LD.
Mårten Risling (339954)   +9 more
core   +1 more source

Resolving the biome debate: ecological and palaeo‐data concur that the extensive tree‐limited grassy biomes of central and north‐western Madagascar are largely anthropogenic

open access: yesBiological Reviews, EarlyView.
ABSTRACT For millennia, human activities have transformed ecosystems globally. Determining which landscapes are predominantly anthropogenic is crucial to conservation and habitat restoration. Madagascar, a critically‐threatened biodiversity hotspot, is a prominent example.
Grant S. Joseph   +7 more
wiley   +1 more source

Haplotype network showing three distinct groups.

open access: yes, 2018
Each circle represents a unique haplotype and the size of each circle indicates how many specimens share that haplotype, the larger the circle the more specimens sharing an identical haplotype.
Ángel Valdés (466479)   +1 more
core   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul   +5 more
wiley   +1 more source

Haplotype analysis for rs1039084 and rs9399599.

open access: yes, 2013
Graph presents the coefficients with standard error per haplotype. Haplotype 1 was used as reference haplotype. NS = not significant.
Marieke J. H. A. Kruip (316791)   +5 more
core   +1 more source
haplotypes
humans
genotype
algorithms
genetic diversity
linkage disequilibrium
3. good health
models, genetic
polymorphism, single nucleotide
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