Results 101 to 110 of about 209,468 (302)
Clinical Pharmacology &Therapeutics, EarlyView.The chemotherapeutic 5‐fluorouracil (5‐FU) is commonly used to treat solid tumors, especially colorectal cancer. Deleterious variants in DPYD, which encodes dihydropyrimidine dehydrogenase (DPD), are strongly associated with severe and potentially lethal 5‐FU toxicity.
Brianna M. Bembenek +4 more
wiley +1 more source
Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen +10 more
wiley +1 more source
iMetaOmics, EarlyView.Natural populations of Marchantia polymorpha sampled across contrasting climatic regions show clear geographic differentiation between Europe and Japan based on polymorphic short tandem repeat (STR) variation. Genome‐wide association (GWAS) analyses identified pSTR loci whose repeat‐length variation tracks temperature‐related WorldClim variables.
Shuangyang Wu +4 more
wiley +1 more source
, 2015 Shown are the statistical parsimony network based on 10 SRY-haplotypes obtained from 59 males and haplotype distribution on Sulawesi. The white circle indicates an inferred missing haplotype. Mutation steps are shown as hatch marks.
Walberto Sinaga (824911) +5 more
core +1 more source
Genetic switch to lower nitrogen fertilizer dependency and enhance maize yield
iMetaOmics, EarlyView.Transcription factor NCR1 regulates nitrate transporter NRT2.3 and controls root‐to‐shoot nitrogen transport. A superior NCR1 haplotype, lost in modern maize breeding, boosts this process. This discovery enables breeding and biotechnology to develop high‐yielding maize varieties that require less nitrogen fertilizer, reducing agricultural costs and ...
Sunil S. Gangurde +9 more
wiley +1 more source
Hayati Journal of Biosciences, 2008 The Mitochondrial DNA (mtDNA) displacement (D)-loop sequences were used to study the genetic diversity and relationship of Indonesian indigenous chickens.
SRI SULANDARI +2 more
doaj
Haplotype main effect and conditional haplotype-based analysis tests (MHF>0.01).
, 2015 MHF: minor haplotype frequency; H1, H2, H3, H4 represented haplotype1, haplotype2, haplotype3, haplotype4, respectively. S1, S2, S3 represented SNP rs870142, rs16835979, rs6824295, respectively.
Xuejiao Hu (545890) +10 more
core +1 more source
iNew Medicine, EarlyView.ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu +2 more
wiley +1 more source
Genetic Biomarkers in the Risk Assessment of Sudden Cardiac Events: A Personalized Approach
iNew Medicine, EarlyView.Genetic insights into the risk assessment of sudden cardiac events. ABSTRACT Sudden cardiac events are the leading cause of death worldwide. Conventional risk stratification methods, which largely depend on clinical history, imaging, and electrocardiography, are usually inadequate for identifying high‐risk individuals, especially those without visible ...
Shrikant Verma +5 more
wiley +1 more source