Results 91 to 100 of about 209,468 (302)
Clinical Pharmacology &Therapeutics, EarlyView.Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz +5 more
wiley +1 more source
Discovery of Single Nucleotide Polymorphisms in Complex Genomes Using SGSautoSNP
Biology, 2012 Single nucleotide polymorphisms (SNPs) are becoming the dominant form of molecular marker for genetic and genomic analysis. The advances in second generation DNA sequencing provide opportunities to identify very large numbers of SNPs in a range of ...
Jacqueline Batley +10 more
doaj +1 more source
No evidence of a significant role for CTLA-4 in multiple sclerosis [PDF]
, 2006 Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore
Maranian, M +7 more
core
Clinical Pharmacology &Therapeutics, EarlyView.The NAT2 pharmacogene is essential in drug metabolism, particularly for aromatic amines and hydrazines. Genetic variations in NAT2 categorize individuals as rapid, intermediate, or poor metabolizers based on their acetylation capacity to inform dosing guidelines.
Shobana John +4 more
wiley +1 more source
Modeling Haplotype-Haplotype Interactions in Case-Control Genetic Association Studies
Frontiers in Genetics, 2012 Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature ...
Li eZhang +4 more
doaj +1 more source
Diploid Alignments and Haplotyping [PDF]
, 2015 Sequence alignments have been studied for decades under the simplified model of a consensus sequence representing a chromosome. A natural question is if there is some more accurate notion of alignment for diploid (and in general, polyploid) organisms.
Veli Mäkinen, Daniel Valenzuela 0001
openaire +2 more sources
, 2016 Haplotype frequencies estimated for the CRS population compared to the haplotype frequencies of the EUR population.
Christina Lind-Halldén (3163089) +6 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera +15 more
wiley +1 more source