Results 91 to 100 of about 138,927 (255)

Inheritance of bovine lymphocyte intestinal retention defect disorder affects Holstein production performance and longevity

Journal of Dairy Science
: Improved methods previously developed for tracking new mutations within existing haplotypes for cholesterol deficiency (HCD) and muscle weakness (HMW) now also were applied to track the bovine lymphocyte intestinal retention defect (BLIRD) discovered ...
A. Al-Khudhair, D.J. Null, P.M. VanRaden, E.L. Nicolazzi   +3 more
doaj   +1 more source

DPYD and UGT1A1 Genotype‐Based Dosing for Fluoropyrimidines and Irinotecan Chemotherapy: Variant‐Specific Impact on Treatment Intensity and Toxicity

International Journal of Cancer, EarlyView.
Pre‐treatment DPYD and UGT1A1 genotyping is increasingly used to prevent fluoropyrimidine‐ and irinotecan‐related toxicity, but variant‐specific real‐world effects remain unclear. In an unselected cohort of cancer patients with actionable genotypes, genotype‐driven dosing improved safety while preserving treatment exposure in high‐risk DPYD c.1905+1G>A
Martina Gambron, Elena Peruzzi, Samantha Perfler, Marcella Montico, Riccardo Cecchin, Elena De Mattia, Michele Spina, Camilla Lisanti, Serena Corsetti, Luisa Foltran, Fabio Puglisi, Rossana Roncato, Erika Cecchin   +12 more
wiley   +1 more source

Genome-Wide Association Analysis Revealed Candidate Genes Related to Early Growth Traits in Inner Mongolia Cashmere Goats

Veterinary Sciences
The Inner Mongolia cashmere goat is a local breed valued for both its cashmere and meat production. Early growth traits include birth weight and weaning weight.
Youjun Rong, Xiaofang Ao, Furong Guo, Xinle Wang, Mingxuan Han, Lu Zhang, Qincheng Xia, Fangzheng Shang, Qi Lv, Zhiying Wang, Rui Su, Yanhong Zhao, Yanjun Zhang, Ruijun Wang   +13 more
doaj   +1 more source

The importance of gene polymorphism in familial inheritance of endometriosis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The study aimed to investigate familial transmission patterns in women with endometriosis by generating a customized single‐nucleotide polymorphism (SNP) array. Methods Patients aged 18–45 who were diagnosed histopathologically with endometriosis were included in the study.
Hale Goksever Celik, Candan Eker, Berivan Guzelbag, Ercan Bastu, Tuba Gunel   +4 more
wiley   +1 more source

Association Between Interleukin‐6 Promoter Polymorphisms and Disease Susceptibility: A Review of Current Evidence

iLABMED, EarlyView.
IL‐6 SNPs contribute to the pathogenesis of diverse diseases by altering gene expression, and hold potential as biomarkers for disease risk assessment. ABSTRACT Interleukin 6 (IL‐6), a type of cytokine, plays a role in the onset, progression, and prognosis of various diseases.
Junyi Li, Yiling Xv, Qingfeng Ma, Wei Wang   +3 more
wiley   +1 more source

Polymorphic STRs represent unique genetic signals beyond SNPs associated with climate adaptation in Marchantia polymorpha

iMetaOmics, EarlyView.
Natural populations of Marchantia polymorpha sampled across contrasting climatic regions show clear geographic differentiation between Europe and Japan based on polymorphic short tandem repeat (STR) variation. Genome‐wide association (GWAS) analyses identified pSTR loci whose repeat‐length variation tracks temperature‐related WorldClim variables.
Shuangyang Wu, Shenghan Gao, Sen Wang, Martin Lascoux, Hao Yu   +4 more
wiley   +1 more source

Morphological Characterization and Assessment of Genetic Variability of Tylenchulus semipenetrans Populations from Southern Iran

Journal of Nematology
Molecular data should be combined with morphological data to enhance the reliability of phylogenetic and diagnostic studies on nematodes. In this study, the citrus nematode Tylenchulus semipenetrans collected from citrus orchards in different localities ...
Rumiani Mohammad, Zouhar Miloslav, Karegar Akbar, Hamzehzarghani Habiballah, Tahmasebi Ahmad, Rashidifard Milad   +5 more
doaj   +1 more source

Genetic switch to lower nitrogen fertilizer dependency and enhance maize yield

iMetaOmics, EarlyView.
Transcription factor NCR1 regulates nitrate transporter NRT2.3 and controls root‐to‐shoot nitrogen transport. A superior NCR1 haplotype, lost in modern maize breeding, boosts this process. This discovery enables breeding and biotechnology to develop high‐yielding maize varieties that require less nitrogen fertilizer, reducing agricultural costs and ...
Sunil S. Gangurde, Dhliwayo Thanda, Qingguo Du, Liang Li, Jiwang Zhang, Pervez H. Zaidi, Boddupalli Maruthi Prasanna, Xuecai Zhang, Linmao Zhao, Ashish Saxena   +9 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

A Tripartite Model for EBV‐Driven Multiple Sclerosis: B Cell Survival, Altered Self‐Presentation, and HLA‐DR15‐Restricted T Cell Cross‐Reactivity

iNew Medicine, EarlyView.
ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu, Arnaud John Kombe Kombe, Tengchuan Jin   +2 more
wiley   +1 more source