Results 61 to 70 of about 277,505 (282)

Computational analyses of ancient pathogen DNA from herbarium samples: challenges and prospects

Frontiers in Plant Science, 2015
The application of DNA sequencing technology to the study of ancient DNA has enabled the reconstruction of past epidemics from genomes of historically important plant-associated microbes.
Kentaro eYoshida, Kentaro eYoshida, Eriko eSasaki, Sophien eKamoun   +3 more
doaj   +1 more source

Polymorphisms in the Human Aquaporin 4 Gene Are Associated With Schizophrenia in the Southern Chinese Han Population: A Case–Control Study

Frontiers in Psychiatry, 2020
BackgroundIn psychiatric illness, pathogenic role of neuroinflammation has been supported by multiple lines of evidence. Astrocytes contribute to the blood-brain barrier (BBB) with formation of the “glymphatic” drainage system of the central nervous ...
Yung-Fu Wu, Yung-Fu Wu, Huey-Kang Sytwu, For-Wey Lung, For-Wey Lung   +4 more
doaj   +1 more source

Screening tests for Disease Risk Haplotype Segments in Genome by Use of Permutation [PDF]

, 2015
The haplotype association analysis has been proposed to capture the collective behavior of sets of variants by testing the association of each set instead of individual variants with the disease.
Ali, Fadhaa, Zhang, Jian
core  

Rapid turnover of T cells in acute infectious mononucleosis.

, 2003
During acute infectious mononucleosis (AIM), large clones of Epstein-Barr virus-specific T lymphocytes are produced. To investigate the dynamics of clonal expansion, we measured cell proliferation during AIM using deuterated glucose to label DNA of ...
Asquith, Becca, Beverley, Peter C, Ghattas, Hala, Griffin, George E, Irvine, Andrew J, Macallan, Derek C, Tough, David F, Wallace, Diana L, Worth, Andrew, Zhang, Yan   +9 more
core   +1 more source

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

Long-range, high-throughput haplotype determination via haplotype-fusion PCR and ligation haplotyping [PDF]

Nucleic Acids Research, 2008
Ligation Haplotyping is a robust, novel method for experimental determination of haplotypes over long distances, which can be applied to assaying both sequence and structural variation. The simplicity and efficacy of the method for genotyping large chromosomal rearrangements and haplotyping SNPs over long distances make it a valuable and powerful ...
Turner, Daniel J., Tyler-Smith, Chris, Hurles, Matthew E.   +2 more
openaire   +2 more sources

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Linking unfounded beliefs to genetic dopamine availability

Frontiers in Human Neuroscience, 2015
Unfounded convictions involving beliefs in the paranormal, grandiosity ideas or suspicious thoughts are endorsed at varying degrees among the general population.
Katharina eSchmack, Hannes eRössler, Maria eSekutowicz, Eva J Brandl, Daniel J Mueller (Müller), Predrag ePetrovic, Philipp eSterzer   +6 more
doaj   +1 more source

Haplotype inference for present–absent genotype data using previously identified haplotypes and haplotype patterns [PDF]

Bioinformatics, 2007
AbstractMotivation: Killer immunoglobulin-like receptor (KIR) genes vary considerably in their presence or absence on a specific regional haplotype. Because presence or absence of these genes is largely detected using locus-specific genotyping technology, the distinction between homozygosity and hemizygosity is often ambiguous.
Yun Joo, Yoo, Jianming, Tang, Richard A, Kaslow, Kui, Zhang   +3 more
openaire   +2 more sources

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

Advanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang, Ning Lu, Xin‐Xiu Lin, Xu‐Hui Fang, Yi‐Hui Li, Qing‐Peng Luo, Yu‐Ting Peng, Gil Mor, Ai‐Hua Liao   +8 more
wiley   +1 more source