Results 131 to 140 of about 127,421 (299)

PROTRACTED DIARRHOEA AND AUTOIMMUNE ENTEROPATHY: A GENERALISED AUTOIMMUNE GUT DISORDER WITH A COMMON HLA HAPLOTYPE [PDF]

, 1989
S. Hill, Rita Mirakian, Peter J. Milla
openalex   +1 more source

From Genotype to Therapeutic Monitoring: Enhancing Tamoxifen Efficacy in Breast Cancer Treatment

The Journal of Clinical Pharmacology, EarlyView.
Abstract Endoxifen is the most active metabolite of tamoxifen and plays a central role in its therapeutic efficacy. However, significant interindividual variability in endoxifen plasma concentrations, driven by both genetic and non‐genetic factors, may result in subtherapeutic exposure for a substantial subset of patients.
Ana Flávia Mendes Batista, Letícia Penteado Petrolli, Maria Paula Marques Pereira, Adriana Rocha, Jurandyr Moreira de Andrade, Vera Lucia Lanchote, João Paulo Bianchi Ximenez   +6 more
wiley   +1 more source

Chronic atrial and intestinal dysrythmia syndrome: A late‐onset intestinal pseudo‐obstruction and cardiac dysfunction due to an SGO1 mutation

JPGN Reports, EarlyView.
Abstract Objectives Pediatric intestinal pseudo‐obstruction (PIPO) is a rare, heterogeneous, and severe gut motility disorder. In 2014, Chetaille et al. described chronic atrial and intestinal dysrhythmia (CAID) syndrome associated with a recessive SGO1 mutation (p.Lys23Glu) linking it to both intestinal pseudo‐obstruction and cardiac dysrhythmia. This
Linda Adouane, Pierre Poinsot, Julie Castilloux, Dorothée Dal Soglio, Christophe Faure   +4 more
wiley   +1 more source

Epidemiology of Pemphigus in Morocco

JEADV Clinical Practice, EarlyView.
ABSTRACT Background The global distribution of pemphigus varies according to genetic, ethnic, socioeconomic, and cultural backgrounds. Despite the increased utilization of global health records and reporting systems, epidemiological data remain limited and poorly categorized.
Amani Fliti, Meryem Elomari Alaoui, Hanane Baybay, Fatima Zahra Mernissi, Fouzia Hali, Soumiya Chiheb, Nada Zizi, Siham Dikhaye, Ouafa Hocar, Amal Said, Ghita Basri, Fatima Zahra Agharbi, Hicham Titou, Naoufal Hjira, Ouiame El Jouari, Salim Gallouj, Mohamed Ait Ourhroui, Radia Chakiri, Jalal Elbenaye, Laila Benzekri, Karima Senouci   +20 more
wiley   +1 more source

Ecophysiology of two mesophotic octocorals intended for restoration: Effects of light and temperature

Limnology and Oceanography, EarlyView.
Abstract Light and temperature are driving forces that shape the evolution and physiology of mesophotic organisms. On the Mississippi‐Alabama continental shelf, octocorals dominate the mesophotic seascape and provide habitat for many fish and invertebrate species.
Kassidy Lange, Allisan Aquilina‐Beck, Mark McCauley, Julia Johnstone, Amanda Demopoulos, Thomas Greig, Jody M. Beers, Heather L. Spalding, Peter J. Etnoyer   +8 more
wiley   +1 more source

Complementation of Major Histocompatibility Haplotypes in Regression of Rous Sarcoma Virus-Induced Tumors in Noninbred Chickens ,

, 1982
David W. Brown, W.M. Collins, Paul H. Ward, W. Elwood Briles   +3 more
openalex   +1 more source

Suppression of H-2b-associated resistance to Friend erythroleukemia virus by a class I gene from the H-2d major histocompatibility complex haplotype. [PDF]

, 1991
David Polsky, F Lilly
openalex   +1 more source

Huntington's Disease and Huntington's Disease‐like 2 (HDL2) in Martinique

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Huntington's Disease‐like 2 (HDL2), caused by a CAG repeat expansion in JPH3, closely resembles HD. All reported HDL2 patients to date have some African ancestry. While both disorders exist in the Caribbean, their relative frequency and clinical characteristics remain largely unknown.
Ignacio Antolin‐Sanfeliz, Anna‐Gaelle Giguet‐Valard, Sophie Duclos, Cécile Cazeneuve, Chloé Angelini, Aïssatou Signaté, Russell L. Margolis, Cyril Goizet, Rémi Bellance   +8 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

A CGG Repeat Expansion in CSNK1E Associated with Progressive Myoclonic Epilepsy with Incomplete Penetrance

Movement Disorders, EarlyView.
Abstract Background Progressive myoclonic epilepsy is a heterogeneous neurodegenerative disorder characterized by early‐onset myoclonus, epilepsy, generalized tonic–clonic seizures, and progressive neurological deterioration. Recently, a CGG repeat expansion and increased CSNK1E DNA methylation have been shown to be associated with developmental and ...
Fulya Akçimen, Pilar Alvarez Jerez, Ulviyya Guliyeva, Jasmine Lee, Laksh Malik, Breeana Baker, Kamran Salayev, Sughra Guliyeva, Kimberley J. Billingsley, Henry Houlden, Andrew B. Singleton, Cornelis Blauwendraat, Sara Bandres‐Ciga, Rauan Kaiyrzhanov   +13 more
wiley   +1 more source