Results 121 to 130 of about 156,383 (305)

New Chloroplast Microsatellites in Helichrysum italicum (Roth) G. Don: Their Characterization and Application for the Evaluation of Genetic Resources

Plants
Helichrysum italicum (Roth) G. Don is a Mediterranean medicinal plant with great potential in the cosmetics, culinary and pharmaceutical fields due to its unique bioactive compounds.
Matjaž Hladnik, Alenka Baruca Arbeiter, Petra Gabrovšek, Félix Tomi, Marc Gibernau, Slavko Brana, Dunja Bandelj   +6 more
doaj   +1 more source

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

ACE haplotypes. [PDF]

, 2018
ACE haplotypes.
Clarence C. Gravlee (370512), Kia C. Fuller (5759408), Connie J. Mulligan (39895), Christopher McCarty (3859360), Cynthia Seaborn (5759411)   +4 more
core   +1 more source

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Distribution of repeated haplotypes. [PDF]

, 2019
Distribution of repeated haplotypes.
Barbara Scherm (381434), Angela Marcello (8173992), Maria Aragona (4098790), Virgilio Balmas (381435), Domenico Rau (261604), Maria Teresa Valente (8173989), Francesca Desiderio (2588137), Sengphet Phanthavong (8173995), Lester W. Burgess (8173998), Alessandro Infantino (4098784)   +9 more
core   +1 more source

Resolving CYP2D6 Structural Complexity with Long‐Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cytochrome P450 2D6 (CYP2D6)‐mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor‐positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype–phenotype correlation.
Usa Boonyuen, Sirinyatorn Talukam, Beatriz Aira C. Jacob, Wayu Matphong, Kamonwan Chamchoy, Onrapak Reamtong, Nuntana Meesiripan, Junya Yamagishi, Matthew Phanchana, Chayanoot Rattadilok   +9 more
wiley   +1 more source

Tomato SuSy4 haplotypes (812aa). [PDF]

, 2018
Tomato SuSy4 haplotypes (812aa).
Quy-Dung Dinh (5905046), Richard Finkers (1386879), Luisa M. Trindade (657220), Walter M. A. M. van Dongen (5905049), Richard G. F. Visser (52153), Adrie H. Westphal (135102)   +5 more
core   +1 more source

Pattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke

Pharmacogenomics and Personalized Medicine, 2021
Gohar Tsakanova,1,2 Ani Stepanyan,1 Rudi Steffensen,3 Armine Soghoyan,4 Jens Christian Jensenius,5 Arsen Arakelyan1 1Institute of Molecular Biology NAS RA, Yerevan, Armenia; 2CANDLE Synchrotron Research Institute, Yerevan, Armenia; 3Department of ...
Tsakanova G, Stepanyan A, Steffensen R, Soghoyan A, Jensenius JC, Arakelyan A   +5 more
doaj  

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, EarlyView.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

The diploid origins of allopolyploid rose species studied using single nucleotide polymorphism haplotypes flanking a microsatellite repeat [PDF]

, 2013
The taxonomy of the genus Rosa is complex, not least because of hybridisations between species. We aimed to develop a method to connect the diploid Rosa taxa to the allopolyploid taxa to which they contributed, based on the sharing of haplotypes.
Smulders, MJM (reprint author), Chinese Acad Sci, Chengdu Inst Biol, POB 416, Chengdu 610041, Sichuan, Peoples R China., Arens, P., Che, D., Smulders, M. J. M., Fougere-Danezan, M., Esselink, G. D., Zhang, J.   +6 more
core