Results 171 to 180 of about 20,143 (219)
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1986
The haptoglobin molecule consists of α- and β-chains linked with disulfide bridges. The isoelectric heterogeneity observed in the β-chain is due to its content of sialic acid. The α-chain shows genetically determined structural polymorphism, and the most common subtypes 1S, 1F, 2FS, 2SS, 2FF and Johnson may be separated by isoelectric focusing (1,2). A
Brita Teige +2 more
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The haptoglobin molecule consists of α- and β-chains linked with disulfide bridges. The isoelectric heterogeneity observed in the β-chain is due to its content of sialic acid. The α-chain shows genetically determined structural polymorphism, and the most common subtypes 1S, 1F, 2FS, 2SS, 2FF and Johnson may be separated by isoelectric focusing (1,2). A
Brita Teige +2 more
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Canadian Journal of Biochemistry, 1970
Alpha chains of human haptoglobin have been prepared from whole haptoglobin of genetic type Hp 2–1 purified from the ascites fluid of a single patient. Amino acid sequence analysis has been carried out on these light chains which represent the products ...
J. A. Black, G. H. Dixon
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Alpha chains of human haptoglobin have been prepared from whole haptoglobin of genetic type Hp 2–1 purified from the ascites fluid of a single patient. Amino acid sequence analysis has been carried out on these light chains which represent the products ...
J. A. Black, G. H. Dixon
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Properties of sulfanilazo-haptoglobin
International Journal of Biochemistry, 19881. Tyrosine and two structural isomers of histidine residues in human haptoglobin were modified with diazotized sulfanilic acid. Sulfanilazo-derivatives of haptoglobin obtained by increasing the reagent/protein molar ration showed gradual decrease of peroxidase activity when complexed with hemoglobin. 2.
Tadeusz Guszczyński, Wanda Dobryszycka
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Haptoglobin in Pernicious Anemia
Scandinavian Journal of Clinical and Laboratory Investigation, 1957Haptoglobin (Hp) is a term introduced by Jayk (1939) to designate a group of serum mucaproteins capable of binding hemoglobin stoechiometrically in Vim and in vitro. The haptoglobin content of the serum can be determined by two merhods, both based on the affinity of haptoglobin for hemoglobin.
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Haptoglobin Subtypes in Hungary
Human Heredity, 1976Hb subtyping on a sample of 343 donors in Budapest resulted in the following gene frequencies: Hp1F = 0.139; Hp1S = 0.210; Hp2 = 0.651.
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Haptoglobin: A Natural Bacteriostat
Science, 1982The combination of bacteria and blood in a wound can have lethal consequences, probably because hemoglobin iron supports prolific bacterial growth. Rats inoculated intraperitoneally with pathogenic Escherichia coli and small amounts of hemoglobin die. Simultaneous administration of haptoglobin, a naturally occurring
Paul Brandt +3 more
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Fragmentation of Haptoglobin by Plasmin
Canadian Journal of Biochemistry, 1971Human haptoglobin type Hp 1-1, is hydrolyzed by plasmin to give two dissimilar products, P1 and P2, with molecular weights of 78 000 and 17 000, respectively. The larger fragment, P1 has the same N-terminal amino acids, valine and isoleucine, as intact haptoglobin.
Frederick A. Ofosu +2 more
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Haptoglobin Polymorphism and Infection
2010The haptoglobin gene is highly polymorphic in humans with strong evidence of functionally distinct biochemical phenotypes. In all human populations, three major haptoglobin phenotypes Hp 1-1, Hp 2-1, and Hp 2-2 are present, but additional phenotypes have been identified. Haptoglobin polymorphism has important biological and clinical significance.
Ishmael Kasvosve +4 more
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Haptoglobin, inflammation and disease
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2008Haptoglobin is an acute phase protein that scavenges haemoglobin in the event of intravascular or extravascular haemolysis. The protein exists in humans as three main phenotypes, Hp1-1, Hp2-2 and Hp2-1. Accumulated data on the protein's function has established its strong association with diseases that have inflammatory causes. These include parasitic (
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Haptoglobin in Thalassemia [PDF]
Acta Haematologica, 1969 B. Yamak, S. Özsoylu
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