Results 71 to 80 of about 7,568 (236)

Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li, Pushpa Dhilipkannah, Van K Holden, Ashutosh Sachdeva, Feng Jiang   +4 more
wiley   +1 more source

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden, Craig J McClain, Zhongbin Deng   +11 more
wiley   +1 more source

Identification of haptoglobin as an endogenous inhibitor of prostaglandin H synthase in the cytosol fraction of primary cells from sheep vesicular glands [PDF]

, 1990
R. U. Beisembaeva, A.T. Mursagalieva, L.M. Dzhumalieva, Tattym E. Shaiken, A.T. Mevkh   +4 more
openalex   +1 more source

A Diagnostic Challenge: Post‐Transfusion Purpura Unmasked After Multiple Transfusions

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Post‐transfusion purpura (PTP) is a rare immune‐mediated post‐transfusion reaction resulting in severe thrombocytopenia. This case presents a 52‐year‐old female with profound thrombocytopenia following multiple transfusions. PTP was not initially suspected due to her history of comorbid anti‐phospholipid antibody syndrome (APS), chemotherapy ...
Jacintha Thomas, Priyal Gopalan, Tanya M. Wildes   +2 more
wiley   +1 more source

Haptoglobin and Gc Types in the Haida Indians [PDF]

, 1967
Cecile A. Lovett
openalex   +1 more source

Serum Haptoglobin as a Predictor of Treatment Response in Patients With Chronic Spontaneous Urticaria

Clinical and Translational Allergy, Volume 16, Issue 1, January 2026.
ABSTRACT Background Chronic spontaneous urticaria (CSU) is a mast cell‐driven disease associated with systemic inflammation and altered immune responses. Haptoglobin (HP), an acute‐phase glycoprotein, exhibits antioxidative and immunomodulatory properties, while zonulin, the precursor of HP‐2, regulates epithelial barrier integrity. We investigated the
Kun‐Woo Park, Boyoun Choi, Da‐Hye Moon, Se‐Min Park, Young‐Min Ye   +4 more
wiley   +1 more source

MUC4 mutations promote a thrombotic phenotype in patients with paroxysmal nocturnal haemoglobinuria by increasing the deposition of terminal complement

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
1. PNH patients lack the complement regulatory proteins CD55 and CD59, triggering excessive activation of the terminal complement pathway and a prothrombotic state. 2. MUC4 mutation is an independent thrombotic risk factor in PNH. 3. Mutation/down‐regulation of MUC4 promotes the abnormal deposition of excessively activated terminal complement ...
Yingying Chen, Mengting Che, Chaomeng Wang, Qiaoyi Bronte Zhang, Weixin Chen, Hui Liu, Chunyan Liu, Guang Sheng Ling, Rong Fu   +8 more
wiley   +1 more source

Corrigendum to “Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta‐Analysis” [PDF]

, 2018
Ben Gaastra, James J. Glazier, Diederik Bulters, Ian Galea   +3 more
openalex   +1 more source

Stable immune function during moult regardless of age‐specific moulting strategy in a European passerine

Journal of Avian Biology, Volume 2026, Issue 1, January 2026.
Moult, the regular replacement of feathers, is a resource‐intense avian annual‐cycle stage. Resource allocation to support feather regrowth may require downregulation of other physiological processes, such as immune function, which is critical for preventing disease‐related mortality.
Malin V. Klumpp, Arne Hegemann
wiley   +1 more source

Robust Diagnostic and Therapeutic Biomarkers for Tuberculosis Identified Through Multi‐Omics and Mendelian Randomization Analysis

MedComm, Volume 7, Issue 1, January 2026.
We performed UPLC‐MS/MS lipidomics and DIA proteomics on plasma from healthy controls, active TB patients, and cured patients, and used Mendelian randomization to prioritize diagnostic and cure biomarkers. Multi‐omics random‐forest models based on these biomarkers showed excellent performance for diagnosis and cure monitoring.
Chenglin Zhu, Jiaxi Chen, Ying Li, Qi Zhang, Qiqi Lu, Ningxuan Zhang, Hao Fan, Muhammad Mahtab Aslam Khan Khakwani, Lei Zhang, Ji‐Cheng Li   +9 more
wiley   +1 more source