Results 71 to 80 of about 101,392 (202)

TGF‐β Inhibitor Potentiates Osimertinib‐Induced Anti‐Tumor Immunity in Egfr‐Mutant Lung Cancer

Cancer Science, EarlyView.
Osimertinib enhances CD8+ T cell activity but also upregulates immunosuppressive TGF‐β in Egfr‐mutant lung tumors. This study demonstrates that TGF‐β inhibition with nintedanib or vactosertib potentiates osimertinib‐induced CD8+ T cell–mediated immunity and reduce CD206+ macrophages. These findings provide a strong rationale for novel immunotherapeutic
Tadahiro Kuribayashi, Jun Nishimura, Sachi Okawa, Masataka Taoka, Shunta Mori, Takaaki Tanaka, Tomoka Nishimura, Ayako Morita, Naofumi Hara, Kiichiro Ninomiya, Go Makimoto, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Yosuke Togashi, Yoshinobu Maeda, Katsuyuki Kiura, Kadoaki Ohashi   +17 more
wiley   +1 more source

Développement folliculaire terminal : évolution biochimique du follicule

INRAE Productions Animales, 1999
Cet article fait partie du dossier Actualités en reproduction ...
N. GÉRARD
doaj   +1 more source

Aktywność turystyczna argentyńskiej Polonii na przykładzie mieszkańców Buenos Aires – w świetle badań pilotażowych

Prace Komisji Geografii Przemysłu Polskiego Towarzystwa Geograficznego, 2020
Głównym celem badań jest określenie aktywności turystycznej argentyńskiej Polonii na przykładzie mieszkańców Buenos Aires. W 2017 i 2018 roku przeprowadzone zostały pilotażowe badania ankietowe, dzięki którym uzyskana została informacja dotycząca ...
Kamila Ziółkowska-Weiss, Ewelina Haras   +1 more
doaj   +1 more source

Methods for Studying Union Effects: A Review and Comparative Analysis of Empirical Industrial Relations Literature

Industrial Relations Journal, EarlyView.
ABSTRACT This paper reviews methodological developments in Industrial Relations (IR) research on union effects from 1990 to 2023, based on 511 studies in six leading IR journals in the United States, the United Kingdom, Canada, and Australia. We find that institutional contexts shape methodological choices over time and note a general shift from ...
Kwon Hee Han, Tingting Zhang, J. Ryan Lamare   +2 more
wiley   +1 more source

Amniotic fluid is important for the maintenance of maternal responsiveness and the establishment of maternal selectivity in sheep

Animal, 2010
Amniotic fluid (AF) is important for the establishment of maternal behaviour in inexperienced ewes, but its role in experienced mothers remains to be studied. Here, the maintenance of post-partum maternal responsiveness and the establishment of exclusive
P. Poindron, J. Otal, G. Ferreira, M. Keller, V. Guesdon, R. Nowak, F. Lévy   +6 more
doaj   +1 more source

Fathers Are Frightened but May Not Know It: Considering Masculinity and Attachment When Working With Fathers in Family Therapy

Journal of Family Theory &Review, EarlyView.
ABSTRACT Given the often‐unacknowledged emotional realities in theory and practice around masculinities and fatherhood, working with fathers in family therapy needs ongoing attention. Therapists' efforts can be enhanced through attending to how men and fathers may have been socialized towards restrictive masculine ideologies (e.g., devaluing emotional ...
Allen K. Sabey, Jakob F. Jensen, Brandon Jacobs   +2 more
wiley   +1 more source

Pâturage pour vaches laitières. Effets du chargement et de la complémentation en pâturage tournant simplifié

INRAE Productions Animales, 1991
Trois essais, chacun d’une durée moyenne de 6 mois, ont été répétés de 1986 à 1988 sur les mêmes surfaces du domaine INRA du Pin au Haras selon la technique du pâturage tournant simplifié (2 parcelles au printemps, 4 en automne).
A. HODEN, A. MULLER, J.L. PEYRAUD, L. DELABY, P. FAVERDIN, J.R. PECCATTE, M. FARGETTON   +6 more
doaj   +1 more source

Thermal Buffering, Heat Advection and Crustal Thinning in the Ryoke Metamorphic Complex, Yanai, Southwest Japan

Journal of Metamorphic Geology, EarlyView.
ABSTRACT The metamorphic zoning and geothermobarometry of the Ryoke metamorphic complex in the Yanai area, southwest Japan, show that its thermobaric structure was buffered by the dehydration melting of biotite. The temperatures over most of the area covered by the three high‐grade zones (8.5‐ to 19.0‐km depth) are consistent with those of the ...
Takeshi Ikeda, Kazuhiro Miyazaki, Yu Sugawara, Risa Hayashi   +3 more
wiley   +1 more source

Etude de la réactivité émotionnelle chez la caille : une approche intégrée du bien-être animal

INRAE Productions Animales, 2008
Certaines réactions émotionnelles, telles que les réactions de peur, peuvent être inadaptées en élevage, sources d’atteintes au bien-être des animaux.
S. RICHARD , C. ARNOULD , D. GUÉMENÉ , C. LETERRIER , S. MIGNON-GRASTEAU, J.M. FAURE   +5 more
doaj   +1 more source

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications

Journal of Anatomy, Volume 246, Issue 4, Page 585-601, April 2025.
The extracellular matrix plays a critical role in modulating cell behaviour in the central nervous system influencing neural cell morphology and growth. However, a better understanding of the impact of individual matrix proteins on both neurons and astrocytes is critical for advancing the development of matrix‐based neural repair strategies.
Cian O'Connor, Rena E. Mullally, Sarah F. McComish, Julia O'Sullivan, Ian Woods, Ingmar Schoen, Massimiliano Garre, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +9 more
wiley   +1 more source