Results 41 to 50 of about 86,778,281 (282)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Systematic Investigation of a Safer Polyacrylamide Gel Synthesis for MgO Nanoparticles with Tailored Properties

Micro
Magnesium oxide (MgO) nanoparticles, recognized for their versatile applications from catalysis to biomedicine, require synthesis methods that offer precise control over their properties while ensuring safety and scalability. This study explores a safer,
Hedi Ben Ahmed, Maxim Pryazhnikov, Jessica Pirogovskaya, Sergey Zharkov, Il’ya Bril’, Andrey Minakov   +5 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The experience of rational development of hydrocarbon resources in the Earth’s interior used in the new paradigm of Academician A.E. Kontorovich – the development of oil and gas complex of Russia

Georesursy, 2020
The Republic of Tatarstan has accumulated vast experience in the exploration and development of oil fields of various ranks – from small and smallest to giant and supergiant.
Renat Kh. Muslimov
doaj   +1 more source

Definition of the geological structure of deposits of Tyumen suite based on the results of tectonic-sedimentary analysis of the eastern part of the Krasnoleninsky arch of Western Siberia

Известия высших учебных заведений: Нефть и газ, 2023
We present in this article results of an analysis of materials of a complex of geological and geophysical studies, including a description of the core data, facies' characteristics, tectonic features of the evolution of the territory, field development ...
S. R. Bembel, R. M. Bembel, V. O. Rogozhneva   +2 more
doaj   +1 more source

Classification of Hard-to-Recover Reserves Based on FCM and Combination weighting approach [PDF]

, 2013
Currently, the classification criterion of reserves were determined by the scope of the values of criteria such as geological attributes, reservoir phydical parameters and etc., which required all attribute values of one block were just right in the ...
Kejun, Zhu, Zhi, Li, Juan, Yang
core  

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Temperature field in a cylindrical porous layer during “endless” heating with heat outflow

Известия высших учебных заведений: Проблемы энергетики
RELEVANCE. This article proposes a mathematical model for calculating the temperature field in the annular porous layer of an downhole reactor during continuous heating of a bottomhole zone containing high-viscosity oil (VVN) and natural bitumen (PB ...
N. D. Yakimov, A. F. Shageev, A. V. Dmitriev, I. A. Mutugullina   +3 more
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source