Results 41 to 50 of about 102,074 (262)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Hard Carbons as Anodes in Sodium-Ion Batteries: Sodium Storage Mechanism and Optimization Strategies

open access: yesMolecules, 2022
Sodium-ion batteries (SIBs) are regarded as promising alternatives to lithium-ion batteries (LIBs) in the field of energy, especially in large-scale energy storage systems.
Liyang Liu   +5 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Microstructure modulation of hard carbon derived from long-flame coal to improve electrochemical sodium storage performances

open access: yesFuel Processing Technology
Widely sourced precursors for hard carbon with high performances are still a major challenge for industrializing sodium-ion batteries. Herein, long-flame coal was adopted as the precursors to prepare hard carbon by carbonization at different temperatures,
Hai-Tao Zeng   +8 more
doaj   +1 more source

Tannin-Derived Hard Carbon for Stable Lithium-Ion Anode

open access: yesMolecules, 2022
Graphite anodes are well established for commercial use in lithium-ion battery systems. However, the limited capacity of graphite limits the further development of lithium-ion batteries.
Ming-Jun He   +7 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Achieving high initial Coulombic efficiency for competent Na storage by microstructure tailoring from chiral nematic nanocrystalline cellulose

open access: yesCarbon Energy, 2022
Although it has been proven that porous, heteroatomic, and defective structures improve Na storage performance, they also severely affect the initial Coulombic efficiency (ICE) due to the huge irreversible capacity in the first cycle, which always limits
Fei Xie   +9 more
doaj   +1 more source

Application of Diluted Electrode Method to Sodium-ion Insertion into Hard Carbon Electrode

open access: yesElectrochemistry, 2023
Herein, the diluted-electrode method is applied to a hard carbon (HC) electrode to estimate sodium-ion (Na+) insertion kinetics. As metallic nickel (Ni) particles do not accommodate Na+ ions in the potential range of 0–2.0 V vs.
Yuki FUJII   +7 more
doaj   +1 more source

Influence of electric spark on hardness of carbon steel

open access: yesScience and Transport Progress, 2014
Purpose. The purpose of work is an estimation of influence of an electric spark treatment on the state of mouldable superficial coverage of carbon steel. Methodology. The steel of fragment of railway wheel rim served as material for research with chemical composition 0.65% С, 0.67% Mn, 0.3% Si, 0.027% P, 0.028% S.
Vakulenko, I. O.   +3 more
openaire   +4 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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