Results 41 to 50 of about 978,883 (282)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiphysics Modeling of Volcanic Unrest at Mt. Ruapehu (New Zealand)

Geochemistry, Geophysics, Geosystems, 2022
Pre‐eruptive signals at the crater lake‐bearing Mt. Ruapehu (New Zealand) are either absent or hard to identify. Here, we report on geophysical anomalies arising from hydrothermal unrest (HTU) and magmatic unrest (MU) using multiphysics numerical ...
Fee Arens, Armando Coco, Joachim Gottsmann, James Hickey, Geoff Kilgour   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

The study of thermal processes during grinding knives from hard-to-cut steels

Известия высших учебных заведений. Поволжский регион:Технические науки, 2023
Background. In modern mechanical engineering, knives made of hard-to-cut steels are widely used, the main advantage of which is increased heat resistance and wear resistance. The knives are subject to high demands on the geometric accuracy of surfaces
T.N. Ivanova, G.V. Kozlov, A.Yu. Muyzemnek   +2 more
doaj   +1 more source

Rainfall runoff features of permeable sidewalk pavement

Journal of Water and Climate Change, 2021
In urban areas, the buildings and pavements make it hard for rainwater to infiltrate into the ground. The hardened underlaying sub-crust has increased the total rainfall runoff, pushing up the peak flood flow.
Liyuan Qiu, Yu Zhang, Sheng Zhang, Jingwei Zhao, Tengfei Wang, Qiang Wang   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Research on the Grinding Performance of an Electroplated Coarse-Grained Diamond Grinding Wheel by Dressing

Machines
The coarse-grained electroplated diamond grinding wheels is increasingly favored in precision grinding of hard and brittle materials owing to its high material removal efficiency, high wear resistance and steady surface contour accuracy.
Yongqi Xia, Shibo Deng, Mingtao Wu, Binkun Ni   +3 more
doaj   +1 more source

Prediction of mining-induced seismicity and damage assessment of induced surface buildings in thick and hard key stratum working face: a case study of Liuhuanggou coal mine in China

Frontiers in Earth Science, 2023
Thick and hard key stratum working faces are characterized by frequent mine tremors and significant ground tremors during mining which seriously threaten the safety production of the mine.
Gaoang Wang, Sitao Zhu, Xiufeng Zhang, Yingyuan Wen, Zhijie Zhu, Quanjie Zhu, Liangfu Xie, Jiajie Li, Yi Tan, Tao Yang, Yuanyuan Pu, Chun Zhu, Chun Zhu   +12 more
doaj   +1 more source

Characterisation of the relationship between surface texture and surface integrity of superalloy components machined by grinding [PDF]

, 2013
The surface texture of a machined component is influenced largely by the processing parameters used during machining and hence, there is a relationship between both the formation of the surface texture and surface integrity of the machined component.
Liu, Geng, Liu, Lan, Qin, Yi, Zeng, Quanren   +3 more
core  

Non-Gaussian statistics of electrostatic fluctuations of hydration shells

, 2011
We report the statistics of electric field fluctuations produced by SPC/E water inside a Kihara solute given as a hard-sphere core with a Lennard-Jones layer at its surface.
Allan D. Friesen, Blinc R., Böttcher C. J. F., Dmitry V. Matyushov, Fröhlich H., Hansen J. P., Landau L. D., Landau L. D.   +7 more
core   +1 more source