Results 31 to 40 of about 66,614 (249)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liquidation of Shallow-Lying Post-Mining Excavations

Applied Sciences
This article presents an example of the treatment of rock mass disturbed by shallow mining of hard coal in the Małopolska voivodeship, Poland. Considering various methods of rock mass recognition and ways of eliminating shallow voids, recipes for sealing
Jan Macuda, Krzysztof Skrzypkowski, Albert Złotkowski   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Influence of Lithology on the Characteristics of Wave Propagation and Dynamic Response in Rocky Slope Sites Subject to Blasting Load Via the Discrete Element Method [PDF]

Lithosphere
To investigate the dynamic response and attenuation law of rock slope sites subjected to blasting, three lithological numerical models, including slate (hard rock), tuff (relatively soft rock), and shale (soft rock), are established by using MatDEM.
Danqing Song, Xuerui Quan, Zhuo chen, Dakai Xu, Chun Liu, Xiaoli Liu, Enzhi Wang   +6 more
doaj   +1 more source

Research on the application of stage fracturing technology of L-shaped horizontal well in extra-thick coal seam

Meikuang Anquan, 2023
In the process of extra-thick coal seam mining, the strength of hard roof above the coal seam is high, the breaking step distance is large, and it is difficult to collapse, especially the mining disturbance range is wide, and the rock strata of large ...
MEN Hong, ZHAO Huaquan, DOU Guidong, JIA Zenglin, GAO Yonggang, YAN Bin, XIE Fei, WU Liang
doaj   +1 more source

Site Classification using Multichannel Channel Analysis of Surface Wave (MASW) method on Soft and Hard Ground

Journal of Physics: Conference Series, 2018
Site classification utilizing average shear wave velocity (Vs(30) up to 30 meters depth is a typical parameter. Numerous geophysical methods have been proposed for estimation of shear wave velocity by utilizing assortment of testing configuration, processing method, and inversion algorithm. Multichannel Analysis of Surface Wave (MASW) method is been
M. A. M Ashraf, N. S. Kumar, R. Yusoh, Z. A. M. Hazreek, M. Aziman   +4 more
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Research on the Grinding Performance of an Electroplated Coarse-Grained Diamond Grinding Wheel by Dressing

Machines
The coarse-grained electroplated diamond grinding wheels is increasingly favored in precision grinding of hard and brittle materials owing to its high material removal efficiency, high wear resistance and steady surface contour accuracy.
Yongqi Xia, Shibo Deng, Mingtao Wu, Binkun Ni   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source