Results 131 to 140 of about 615,704 (332)
A condensate-hardening drug blocks RSV replication in vivo
Nature, 2021 Jennifer Risso-Ballester +18 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Bulblet regeneration from ex vitro root explant in lily hybrids
Horticultural Science, 2008 The influence of growth regulators on in vitro bulblet formation from ex vitro roots was studied in asiatic and oriental hybrids of Lilium The root segments (3-4 mm) isolated from the middle zone of 2-3 cm ex vitro root were cultured on Murashige and ...
R. Kapoor, S. Kumar, J. K. Kanwar
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Influence of growth regulators and explants on shoot regeneration in carnation
Horticultural Science, 2009 The influence of growth regulators, explants and their interactions on in vitro shoot bud formation from callus was studied in Dianthus caryophyllus L. The leaf and internode explants were cultured on Murashige and Skoog (MS) medium containing different ...
J. K. Kanwar, S. Kumar
doaj +1 more source
Strain hardening behavior of Mg–Y alloys after extrusion process
, 2019 The strain hardening is an effective mode of enhancing mechanical properties in alloys. In this work, the strain hardening behaviors of Mg-xY (x = 1, 2, and 3 wt%) after extrusion process was investigated using uniaxial tensile tests.
Chaoyue Zhao +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Dielectric molding apparatus Patent [PDF]
, 1971 Dielectric apparatus for heating, fusing, and hardening of organic matrix to form plastic material into shaped ...
King, C. B., Menges, M. J., Swann, R. T.
core +1 more source