Results 141 to 150 of about 367,365 (296)
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Source: Kurt Tucholsky: Gesammelte Werke in zehn Bänden. Herausgegeben von Mary Gerold-Tucholsky und Fritz J. Raddatz, Reinbek bei Hamburg: Rowohlt Verlag, 1975.
openaire +1 more source
AbstractTo cope with the threats of a harsh environment containing energetic particles, scientists and engineers have been developing mitigation strategies and hardening techniques to improve the resilience of electronic systems. Considering that the radiation environment and the operation conditions are known, as it will be shown in this chapter ...
Ygor Quadros de Aguiar +3 more
openaire +1 more source
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
The Transition from Strain Softening to Strain Hardening in Metallic Glasses. [PDF]
Wang Y, Zheng G, Li M.
europepmc +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Superior Strength-Ductility Synergy Enabled by Dual-Level Heterostructure of L1<sub>2</sub> Precipitates and Local Chemical Order in a MPEA. [PDF]
Zhang J, Shen Y, Xue W, Fan Z.
europepmc +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
New beam hardened data correction and its application to artifact reduction in CT images. [PDF]
Kim S +5 more
europepmc +1 more source

