Results 131 to 140 of about 169,796 (260)

Feasibility of Laminar Plasma-Jet Hardening of Cast Iron Surface

open access: yes, 2005
Nontransferred DC laminar plasma jets of stable flow and low impinging pressure acting on the substrate were used to heat W–Mo–Cu cast iron for phase transfer hardening of the surface layer. Substrates were heated in multipass with or without overlapping
潘文霞   +4 more
core   +1 more source

Elastoplastic modeling of fatigue cracks

open access: yesОмский научный вестник
The presented work provides a detailed analysis of modern approaches to creating elastoplastic models of surface crack growth that take into account the influence of the type of biaxial loading on the development of stresses and strains at the crack tip ...
K. A. Vansovich, V. I. Yadrov
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Fire hardening grant guide. Spanish

open access: yes, 2022
Title from PDF cover (viewed on April 11, 2022)."Adaptado de Wildfire Home Retrofit Guide (Guía de Adaptación de Viviendas a los Incendios Forestales), publicación #SP-20-11, con el permiso de la Universidad de Nevada, Extensión de Reno y el Programa ...

core  

Improving the Wear Resistance of the Coulter Anchor for the Placement of Seeds and Fertilizers at Different Specified Depths

open access: yesAgriEngineering
The working parts of soil cultivation and sowing machines operate under conditions of intense abrasive wear. As wear on the working parts increases, the relative unevenness of their travel depth increases, leading to higher traction resistance and ...
Kanat Uteulov   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Research on Method for Contactless Gas-Phase Boron Enrichment of Steels and Alloys Using Powder Boron Sources

open access: yesMetals
Contactless gas-phase boriding is suitable for strengthening the surface of precision steel components because it avoids direct contact between the workpiece and the boriding medium, thereby helping to maintain dimensional accuracy and surface roughness.
Shunqi Mei   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Work-hardening predicition using a dislocation based model for automotive Interstitial Free (IF) steels [PDF]

open access: yes, 2009
With a view to environmental, economic and safety concerns, car manufacturers need to design lighter and safer vehicles in ever shorter development times.
BALAN, Tudor   +5 more
core  

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