Results 101 to 110 of about 909,127 (312)
Harm reduction principles for healthcare settings
Harm Reduction Journal, 2017 BackgroundHarm reduction refers to interventions aimed at reducing the negative effects of health behaviors without necessarily extinguishing the problematic health behaviors completely.
Mary E Hawk +6 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
British medical journal, 2017 Objectives To examine temporal trends in sex and age specific incidence of self harm in children and adolescents, clinical management patterns, and risk of cause specific mortality following an index self harm episode at a young age.
C. Morgan +7 more
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Gambling and public health: we need policy action to prevent harm
British medical journal, 2019 Prevention of harms related to gambling requires investment in population based approaches, say Heather Wardle and ...
H. Wardle +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
A call for SASOP to review their position on the care of ‘transgender and non-binary youth’
South African Journal of PsychiatryNo Abstract ...
Allan Donkin +2 more
doaj +1 more source
TOPICAL ISSUES OF PREVENTION IN THE FIELD OF FIRE SAFETY DURING LICENSE CONTROL: ANALYSIS OF LAW ENFORCEMENT PRACTICE [PDF]
Актуальные вопросы пожарной безопасностиThe article provides an analysis of certain provisions of the program for the prevention of risks of harm (damage) to legally protected values in the implementation of Federal state license controls (supervision) for activities in the field of fire ...
Irina F. Zenkova +3 more
doaj +1 more source
Harm-Benefit Analyses Can Be Harmful
ILAR Journal, 2019 Abstract Harm-benefit analyses (HBAs) are becoming de rigueur with some governmental regulatory agencies and popular with local institutional animal care and use committees (or their equivalents), the latter due, in part, to the adoption of HBAs as an international accreditation standard.
openaire +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source