Results 101 to 110 of about 691,976 (317)
Legal Theory, 2014 ABSTRACTMuch time has been spent arguing about the soundness of “the harm principle.” But in the philosophical literature there is no single such principle; there are many harm principles. And many objections pressed against “the harm principle” are objections to only some of these principles. The first half of this paper draws a number of distinctions
openaire +1 more source
, 2001 This paper explores the utility of expanding the harm reduction paradigm to incorporate vulnerability reduction. The thrust of harm reduction interventions to date, particularly in injection drug use, has been risk reduction. Many interventions have been
Ezard, Nadine, Nadine Ezard
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Harm as a Psychological Concept: Some Fragmentary Reflections
, 2023 This paper outlines the not-so-sharp contours of the concept of harm. It sees harm as largely a psychological concept and argues for the need of a third concept — harm, in addition to the two incumbents upon us — violence and trauma.
Dhar, Anup
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FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
, 2009 There is increasing awareness of the prevalence of deliberate self-harm (DSH) although the phenomenon is still poorly understood. Those who self-harm often have a poor long-term prognosis, yet systematic focused treatment interventions are scarce.
Hepworth, Claire Rachel
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[Video] Harmful Traditional Practices in the Workplace - Guidance for Best Practice 2020
, 2020 This guidance raises awareness of harmful traditional practices (HTPs) to help organisations address this hidden form of abuse. Our recommendations are based on a Rapid Evidence Review of the most up-to-date research, and consultation with a select ...
Khan, Roxanne
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Beyond the Prevention of Harm: Animal Disease Policy as a Moral Question
, 2009 European animal disease policy seems to find its justification in a “harm to other” principle. Limiting the freedom of animal keepers—e.g., by culling their animals—is justified by the aim to prevent harm, i.e., the spreading of the disease. The picture,
Brom, F.W.A. +3 more
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source