Results 141 to 150 of about 518,464 (269)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Intuitive or deliberative dishonesty: The effect of abstract versus concrete victim. [PDF]

PLoS One
Cheng J, Wang H, Liu Y, Wang C, Sun Q, Verschuere B, Sai L.   +6 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Cyberbullying Victimization on Non-Suicidal Self-Injury Among College Students: A Moderated Mediation Model. [PDF]

Psychol Res Behav Manag
Liu Y, Zeng S, Luo X, Cheng W, Chen Y, Zeng Y.   +5 more
europepmc   +1 more source

Comparing self‐harming intentions underlying eating disordered behaviors and NSSI: Evidence that distinctions are less clear than assumed

, 2019
Kathryn R. Fox, Shirley B. Wang, Chelsea Boccagno, Ann F. Haynos, Evan M. Kleiman, Jill M. Hooley   +5 more
openalex   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Perceptions of nicotine harm among adults who use little cigars and cigarillos: A cross-sectional analysis of wave 7 of the Population Assessment of Tobacco and Health (PATH) Study 2022-2023. [PDF]

Tob Induc Dis
Fidalgo A, Halenar MJ, Merson B, Rajan-Sharma AO.   +3 more
europepmc   +1 more source

Entangled Harms: A Reparative Approach to Climate Justice

Marie-Catherine Petersmann
openalex   +1 more source

“This is a question we have to ask everyone”: asking young people about self‐harm and suicide

, 2016
Michelle O’Reilly, Nikki Kiyimba, Khalid Karim   +2 more
openalex   +2 more sources

194. Mandatory Antimicrobial Duration at the Time of Computerized Physician Order Entry: What’s the Harm? [PDF]

, 2018
Alaina Burns, Ann Wirtz, Gina Weddle, Tammy Frank, Richard Ogden, Jennifer L. Goldman   +5 more
openalex   +1 more source