Results 221 to 230 of about 1,143,268 (362)

If Supply-Oriented Drug Policy is Broken, Can Harm Reduction Help Fix It?—Melding Disciplines and Methods to Advance International Drug Control Policy [PDF]

Critics of the international drug control regime contend that supply-oriented policy interventions are not just ineffective, but they also produce unintended adverse consequences. Research suggests their claims have merit.
Victoria A. Greenfield, Letizia Paoli
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Predicting and differentiating accidental and self-harm drug poisonings using health records data. [PDF]

PLOS Ment Health
Simon GE, Wellman RD, Shortreed SM, Johnson E, Sterling SA, Coleman KJ, Ahmedani BK, Yaseen ZS, Mosholder AD.   +8 more
europepmc   +1 more source

Austerity, Harm and Victimisation

, 2016
In the United Kingdom (UK), austerity is the main policy response to the financial crisis that began to unfold in 2007/8 and describes the expansion of a neo-liberal economic policy that positions the poor as the main ‘debt burden’.
Cooper, V.
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Critically Exploring Self-Harm Through Lived Experience Perspectives: A Survivor-Controlled Integrative Review Employing Participatory Methodology. [PDF]

Health Expect
da Cunha Lewin CC, Leamy M, Baldoza S, Jerwood G, Miles E, Foye U, Sweeney A.   +6 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Adolescent Online Gaming in Jordan: A Cross-Sectional Study on Habits and Health Perceptions Through the Health Belief Model. [PDF]

J Child Adolesc Psychiatr Nurs
Khatatbeh H, Al-Dwaikat T, Khatatbeh M, Premusz V, Khatatbeh M, Alkouri O, Alrida N, AlBashtawy M, Al-Sadoon I, Ali AM.   +9 more
europepmc   +1 more source

A no‐brainer for ending AIDS: the case for a harm reduction decade

Journal of the International AIDS Society, 2016
Catherine Cook, Rick Lines, David P Wilson   +2 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source