Results 231 to 240 of about 1,143,268 (362)

Detecting Uncoded Self-Harm in Veterans' Electronic Health Records Using Positive and Unlabeled Learning: Retrospective Cohort Study. [PDF]

J Med Internet Res
Kumar P, Viszolay AD, Upadhayaya R, Moomtaheen F, Greer DR, Bologa CG, Schneider KA, Davis SE, Matheny ME, van der Goes D, Villarreal G, Zhu Y, Tohen M, Malec SA, Yang JJ, Fielstein EM, Lambert CG.   +16 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Scrolling for science: Assessing the quality and accuracy of Crohn's disease-related content on Instagram reels. [PDF]

PLoS One
Madabhushi S, Patel A, Tse-Kang S, Liu A, Amin D, Rupawala A.   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Paediatric suspected non-accidental or intentional self-harm injuries diagnosed after an emergency call: a national population-based cohort study from Denmark. [PDF]

BMJ Paediatr Open
Sørensen K, Søvsø MB, Eggertsen CN, Haythornthwaite G, Mikkelsen S, Christensen EF, Nielsen VML.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Exploring the acceptability of a brief, rapid-access, self-harm focussed talking therapy: a qualitative analysis of patient experiences. [PDF]

BMJ Open
Clements C, Mulholland H, Hunt A, Mills C, Kvamme-Mitchell K, Tahir N, Kullu C, Taylor P, Gabbay M, Saini P.   +9 more
europepmc   +1 more source

Correction: Measuring sustainability of opioid agonist therapy programs in the context of transition from Global Fund Support

Harm Reduction Journal
Raminta Stuikyte, Ivan Varentsov, Catherine Cook, Sergii Dvoriak   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

'I Battle With This Gambling Addiction Every Day'. Learning From Lived Experiences of Recovery to Guide Gambling Harm Prevention Strategies. [PDF]

Health Expect
McCarthy S, Pitt H, Fung P, Potter M, Arnot G, Thomas S.   +5 more
europepmc   +1 more source