Results 71 to 80 of about 909,127 (312)

Expanding access to harm reduction in rural communities through community-informed public health vending machines

Harm Reduction Journal
Background The opioid epidemic continues to disproportionately impact rural communities across the United States, where structural barriers, including geographic isolation, limited public health infrastructure, and heightened stigma, restrict access to ...
Lori Ann Eldridge, Christian Dotson, Lauren Harrell, Marcus Berry, Samantha Bradley, Alicia Brunelli, Jane Casarez, Virginia Fagg, Wendy Odum, Amanda McKenna-Williams, Kathleen L. Egan   +10 more
doaj   +1 more source

Hidden populations: discovering the differences between the known and the unknown drug using populations in the Republic of Georgia

Harm Reduction Journal, 2019
Background The HIV epidemic in Georgia is increasing. Data shows that compared to previous years, Georgia has increasingly more HIV-infected individuals than previous assessments. Select client groups remain hard to reach by harm reduction programs.
M. Gogia, C. Lawlor, N. Shengelia, K. Stvilia, H. F. Raymond   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

‘This is PEEP’ participatory qualitative study: learning from a provincial consultation and advisory group of people with lived and living experience of substance use in British Columbia, Canada

BMJ Open
Objectives To summarise PEEP’s (Professionals for Ethical Engagement of Peers—a group of consultants with lived and living experience of substance use) outputs and gain insights into PEEP’s impact and suggestions for the future.Design Included an ...
Jane A Buxton, Kurt Lock, Charlene Burmeister, Kerolos Daowd, Jessica Lamb, Jenny McDougall, Amirnima Danaei, Paul Choisil, Elizabeth Haywood, Iesha Henderson, Kali Sedgemore   +10 more
doaj   +1 more source

The harms of promoting ‘Zero Harm’ [PDF]

BMJ Quality & Safety, 2019
In this issue, Amalberti and Vincent1 ask ‘what strategies we might adopt to protect patients when healthcare systems and organizations are under stress and simply cannot provide the standard of care they aspire to’. This is clearly a critical and much overdue question, as many healthcare organisations are in an almost constant state of stress from ...
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

‘Gender affirming healthcare’ is not what the family physician needs to know

South African Family Practice
No abstract available.
Janet Giddy, Allan Donkin, Reitze Rodseth   +2 more
doaj   +1 more source

Reducing the nicotine content of tobacco by grafting with eggplant

BMC Plant Biology, 2020
Background Nicotine is a stimulant and potent parasympathomimetic alkaloid that accounts for 96–98% of alkaloid content. A reduction in the amount of nicotine in cigarettes to achieve a non-addictive level is necessary.
Mengjuan Ren, Mengyue Zhang, Huijuan Yang, Hongzhi Shi   +3 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Do Global Trade Distortions Still Harm Developing Country Farmers?

, 2006
We estimate the impact of global merchandise trade distortions and services regulations on agricultural value added in various countries. Using the latest versions of the GTAP database and the GTAP-AGR model of the global economy, our results suggest ...
Kym Anderson, E. Valenzuela
semanticscholar   +1 more source