Results 71 to 80 of about 691,976 (317)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Hate and Harm

, 2023
From a psychological point of view, hate speech can be conceptualized as harmful intergroup communication. In contrast to other forms of incivility, hate speech is directed toward individuals because of their (perceived) social identity. This explains why the harm of hate speech can extend to entire social groups and societies.
openaire   +3 more sources

Hidden populations: discovering the differences between the known and the unknown drug using populations in the Republic of Georgia

Harm Reduction Journal, 2019
Background The HIV epidemic in Georgia is increasing. Data shows that compared to previous years, Georgia has increasingly more HIV-infected individuals than previous assessments. Select client groups remain hard to reach by harm reduction programs.
M. Gogia, C. Lawlor, N. Shengelia, K. Stvilia, H. F. Raymond   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Measuring sustainability of opioid agonist therapy programs in the context of transition from Global Fund support

Harm Reduction Journal
Background Programmatic and financial sustainability of health responses dependent on donor funding has risen as a major concern. In the HIV field in particular, it generated a number of instruments and assessments on sustainability and processes related
Raminta Stuikyte, Ivan Varentsov, Catherine Cook, Sergii Dvoriak   +3 more
doaj   +1 more source

‘Gender affirming healthcare’ is not what the family physician needs to know

South African Family Practice
No abstract available.
Janet Giddy, Allan Donkin, Reitze Rodseth   +2 more
doaj   +1 more source

Reducing the nicotine content of tobacco by grafting with eggplant

BMC Plant Biology, 2020
Background Nicotine is a stimulant and potent parasympathomimetic alkaloid that accounts for 96–98% of alkaloid content. A reduction in the amount of nicotine in cigarettes to achieve a non-addictive level is necessary.
Mengjuan Ren, Mengyue Zhang, Huijuan Yang, Hongzhi Shi   +3 more
doaj   +1 more source

Deliberate Self Harm in Children and Adolescents

This study compared children and adolescents who had deliberately selfharmed (DSH) with those who had not using data routinely collected during assessment at a Child and Adolescent Mental Health Service (CAMHS). The DSH group consisted of 64 boys and 194
McCarthy-Hoffbauer, Iris, McKenzie, Immanuel, Leach, Chris   +2 more
core   +1 more source

The evaluation of Carousel : a therapeutic programme for prisoners who self-harm [PDF]

, 2010
Thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of Counselling Psychology“Prison self-injury rate accelerates at four times the rise in population” (The Howard League for Penal Reform;
Rose, Julia Margaret Scott
core