Results 31 to 40 of about 66,805 (259)
Animals, 2020 Using animals in scientific research is commonly justified on the utilitarian basis that the benefits of scientific progress to human health and society exceed by far the harm inflicted on animals. In an attempt to ensure that this is indeed the case for
Yoram Gutfreund
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From Scalability to Subsidiarity in Addressing Online Harm
Social Media + Society, 2022 Large social media platforms are generally designed for scalability—the ambition to increase in size without a fundamental change in form. This means that to address harm among users, they favor automated moderation wherever possible and typically apply ...
Amy A. Hasinoff, Nathan Schneider
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Retributivists! The Harm Principle Is Not for You! [PDF]
Ethics, 2014 Retributivism is often explicitly or implicitly assumed to be compatible with the harm principle, since the harm principle (in some guises) concerns the content of the criminal law, while retributivism concerns the punishment of those that break the law.
openaire +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi +6 more
wiley +1 more source
The Foundation of Criminalizing Environmental Crimes in Iran: Emphasizing the Principle of Harm and Its Evolution [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i KiyfarīThe right to a healthy environment, closely tied to fundamental rights such as the right to life, has been widely recognized in various legal systems and international instruments.
shirin bayat, yazdan seyghal
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A New Exploration in the Conceptual Scope of the Principle of "Prohibition of Gharar (Risk)" and Its Applicability to the Buying and Selling of "Cryptocurrencies" from the Perspective of Islamic Law [PDF]
پژوهشنامه حقوق اسلامی ∴ Introduction ∴ The legal landscape surrounding transactions necessitates robust regulations to safeguard the interests of the parties involved.
Javad Soltani Fard, Ahmad Mohammadi
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