Results 41 to 50 of about 66,805 (259)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Krzywdzenie a przyzwalanie na krzywdę. Część III: Zewnętrzny kontekst
Analiza i Egzystencja, 2019 Hurting and allowing harm. Part III: External context In this article I defend the thesis that there is a morally significant difference between doing harm (or harming) and merely allowing harm to happen.
Mirosław Rutkowski
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Social Media, Informed Consent, and the Harm Principle
PhilosophiesThis article examines whether social media users can validly consent to their own use of social media. It argues that, whether or not social media use is analogous to public health interventions, there is an obligation to provide users with information ...
Charles Foster
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Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
“We Don’t Want to Talk About It”: Building Trust for Difficult Decisions
Canadian Journal of BioethicsClinical ethicists must be attuned to nonverbal cues and the deeper issues they raise, and be willing and agile to change course, if needed, from discussing goals of care to establishing trust.
Steven Dezort +2 more
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Les Ateliers de l’Ethique, 2008 In this paper, I present a non standard objection to moral impartialism. My idea is that moral impartialism is questionable when it is committed to a principle we have reasons to reject: the principle of self-other symmetry.
Ruwen Ogien
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التطبيقات الفقهية المعاصرةلقاعدة الضرر يزال في مسائل الزواج والطلاق [PDF]
Al-Maǧallah Al-Qānūniyyaẗقاعدة (الضرر يزال)، هي قاعدة عظيمة تبين مرونة الشريعة الإسلامية، وكذا توضح مدي سعة العمل الاجتهادي وقدرته علي مواكبة تغير الزمان والمكان، لاسيما في عصرنا الحاضر الذي كثرت نوازله وتعدت مسائله، وصار كثير من الناس يحللون أمور كثيرة دون السؤال عن حكمها، بل ...
حشمت محمد عبده
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FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source