Results 61 to 70 of about 66,805 (259)
Groundings, 2008 If an agent acts so as to harm only himself, then is state interference with that action ever legitimate? Paternalistic legislation has been the subject of much debate.
Elouisa M. Leonard
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Comparative Study of the Iranian Legal System with International Rules and Regulations Regarding Prevention of Oil and Gas Pollution [PDF]
پژوهشنامه حقوق اسلامی ∴ Introduction ∴ The prevention of pollution, particularly stemming from the oil and gas industry, stands as a pivotal measure in safeguarding the environment from irreparable damage.
Sayyed Fazlollah Mousavi +1 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Why robots should not be delegated with the decision to kill
Connection Science, 2017 The EPSRC first principle of robotics, “robots should not be designed solely or primarily to kill or harm humans, except in the interests of national security”, is challenged in detail here.
Noel Sharkey
doaj +1 more source
The harm principle, personal identity and identity-relative paternalism. [PDF]
J Med Ethics, 2023 Wilkinson D.
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Effect of Diversity Education on Young Adolescents in Japan: Toward the "Do No Harm" Principle. [PDF]
Int J Environ Res Public Health, 2023 Izutsu T +3 more
europepmc +1 more source
The Collapse of the Harm Principle
The Journal of Criminal Law and Criminology (1973-), 1999 In November 1998, fourteen neighborhoods in Chicago voted to shut down their liquor stores, bars, and lounges, and four more neighborhoods voted to close down specific taverns. Chicago's temperance movement reflects a fascinating development in the legal enforcement of morality. Instead of arguing about morals, the proponents of enforcement are talking
openaire +1 more source