The place of supervised injecting facilities within harm reduction: evidence, ethics and policy
Craig Fry +2 more
openalex +1 more source
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
Public Health Implications of Smokeless Tobacco Use as a Harm Reduction Strategy
David A. Savitz +4 more
openalex +2 more sources
Harm reduction for injecting opiate users: an update and implications in China [PDF]
Maja Meise +6 more
openalex +1 more source
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source
Colonial harm in new packaging: Indigenous critiques of the tobacco industry's 'harm reduction' rhetoric. [PDF]
Maddox R +12 more
europepmc +1 more source
Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno +12 more
wiley +1 more source
Barriers and recommendations for harm reduction services among people living with HIV in Manitoba, Canada: a qualitative study. [PDF]
Villacis-Alvarez E +17 more
europepmc +1 more source
Substantial reduction of inappropriate tablet splitting with computerised decision support: a prospective intervention study assessing potential benefit and harm [PDF]
Renate Quinzler +4 more
openalex +1 more source

