Results 41 to 50 of about 703,957 (311)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Method for Responsibility Division of Multi-Harmonic Sources Based on Canonical Correlation Analysis [PDF]

, 2021
Yi Zhang, Youran Wang, Junyu Guo, Zhenguo Shao   +3 more
openalex   +1 more source

Harmonic analysis and the Riemann-Roch theorem

, 2011
This paper is a continuation of papers: arXiv:0707.1766 [math.AG] and arXiv:0912.1577 [math.AG]. Using the two-dimensional Poisson formulas from these papers and two-dimensional adelic theory we obtain the Riemann-Roch formula on a projective smooth ...
A. N. Parshin, A. N. Parshin, D. Osipov, D. V. Osipov, D. V. Osipov, D. V. Osipov, D. V. Osipov, J.-P. Serre   +7 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Harmonic Spectrum of Output Voltage for Space Vector Pulse Width Modulated Ultra Sparse Matrix Converter

Energies, 2018
In a matrix converter, the frequencies of output voltage harmonics are related to the frequencies of input, output, and carrier signals, which are independent of each other.
Tingna Shi, Lingling Wu, Yan Yan, Changliang Xia   +3 more
doaj   +1 more source

Modern Methods of Time-Frequency Warping of Sound Signals [PDF]

, 2015
Tato práce se zabývá reprezentací nestacionárních harmonických signálů s časově proměnnými komponentami. Primárně je zaměřena na Harmonickou transformaci a jeji variantu se subkvadratickou výpočetní složitostí, Rychlou harmonickou transformaci.
Trzos, Michal
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

»What power art thou?«. Zur Harmonik Henry Purcells am Beispiel der Arie des Cold Genius aus King Arthur [PDF]

Zeitschrift der Gesellschaft für Musiktheorie, 2006
Henry Purcell überrascht immer wieder durch ungewöhnliche harmonische Wendungen, so auch in der Arie »What power art thou« des Cold Genius aus seiner Oper King Arthur (1691): Bereits das Orchestervorspiel enthält einige Besonderheiten, die sich weder mit
Cornelius Bauer
doaj   +1 more source

On the Injectivity of the Shifted Funk-Radon Transform and Related Harmonic Analysis [PDF]

, 2022
Boris Rubin
openalex   +1 more source

A gap theorem for $\alpha$-harmonic maps between two-spheres [PDF]

, 1914
In this paper we consider approximations introduced by Sacks-Uhlenbeck of the harmonic energy for maps from $S^2$ into $S^2$. We continue the analysis in [6] about limits of $\alpha$-harmonic maps with uniformly bounded energy.
Lamm, Tobias, Malchiodi, Andrea, Micallef, Mario   +2 more
core   +5 more sources