Results 21 to 30 of about 20,336 (261)

Development of Harmonic Drive Combining Four Arcs for Conventional Kinematic Application

Machines, 2022
This paper proposes a modified harmonic cam, which is used to design a harmonic drive. Conventional harmonic drives using a sinusoidal cam type pertain to an elastic body concept and are thus difficult to design and evaluate.
Taesu Kim, Jongseok Lee, Wonhyeong Jeong, Hansu Jeon, Sehoon Oh   +4 more
doaj   +1 more source

Analysis of trimming in internal gear cutting using normal polar coordinates

Journal of Advanced Mechanical Design, Systems, and Manufacturing
An effective approach to tooth-profile expression using normal polar coordinates has been proposed by Watanabe in 1949, but not applied to practical design.
Yuya MURAYAMA, Satoshi KISHI, Nobuhiko HENMI   +2 more
doaj   +1 more source

Transport by bi-harmonic drives: from harmonic to vibrational mixing

Journal of Physics: Condensed Matter, 2005
Transport in a one-dimensional symmetric device can be activated by the combination of thermal noise and a bi-harmonic drive. The results of extensive simulations allow us to distinguish between two apparently different bi-harmonic regimes: (i) harmonic mixing, where the two drive frequencies are commensurate but not too high; (ii) vibrational mixing ...
Fabio Marchesoni, Peter Hänggi, M. Borromeo, M. Borromeo   +3 more
openaire   +6 more sources

A Study on Hysteresis Stiffness Model and Parameter Identification of Harmonic Gear Transmission based on Genetic Characteristic

Jixie chuandong, 2022
Hysteresis stiffness is an inherent property of harmonic gear drive. In the traditional dynamic modeling of harmonic gear drive，the stiffness is considered as fixed stiffness or piecewise fixed stiffness，which will lead to reduction of the accuracy of ...
Linfeng Qiu, Manyi Chen, Gang Song, Jie Zhang, Ran Yang, Han Zhang   +5 more
doaj  

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Influence of Tooth Profile Parameter of Double-circle-arc Flexspline on Conjugate Characteristic of Harmonic Gear Drive

Jixie chuandong, 2020
In the process of harmonic drive（HD），the double-circular-arc tooth profile（DCTP） can effectively avoid cusp meshing. In order to further optimize the double arc profile and improve the performance of the HD，based on the modified kinematic method exact ...
Anfu Yuan, Shengfeng Qiu, Xukai Shi
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source