Results 51 to 60 of about 280,256 (316)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Open-loop narrowband magnetic particle imaging based on mixed-frequency harmonic magnetization response

open access: yesFrontiers in Medical Technology
IntroductionMagnetic particle imaging (MPI), a radiation-free, dynamic, and targeted imaging technique, has gained significant traction in both research and clinical settings worldwide.
Hongli Yu   +9 more
doaj   +1 more source

Second-Order Nonlinearity in Triangular Lattice Perforated Gold Film due to Surface Plasmas Resonance

open access: yesThe Scientific World Journal, 2014
We have studied the excitation second-order nonlinearity through a triangular lattice perforated gold film instead of square lattice in many papers. Under the excitation of surface plasmas resonance effect, the second order nonlinearity exists in the ...
Renlong Zhou   +7 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A High-Precision Real-Time Temperature Acquisition Method Based on Magnetic Nanoparticles

open access: yesSensors
The unique magnetothermal properties of magnetic nanoparticles enable the development of a high-precision, real-time, noninvasive temperature measurement method with significant potential in the biomedical field.
Yuchang Zhu   +3 more
doaj   +1 more source

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth   +8 more
wiley   +1 more source

Tailoring Third-Harmonic Diffraction Efficiency by Hybrid Modes in High-Q Metasurfaces.

open access: yesNano letters (Print), 2021
Metasurfaces are versatile tools for manipulating light; however, they have received little attention as devices for the efficient control of nonlinearly diffracted light. Here, we demonstrate nonlinear wavefront control through third-harmonic generation
K. Okhlopkov   +11 more
semanticscholar   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

A simple oblique dip model for geomagnetic micropulsations [PDF]

open access: yesAnnales Geophysicae, 1999
It is pointed out that simple models adopted so far have tended to neglect the obliquity of the magnetic field lines entering the Earth's surface. A simple alternative model is presented, in which the ambient field lines are straight, but enter wedge ...
J. A. Lawrie, P. N. Smith
doaj   +1 more source

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