Results 51 to 60 of about 214,301 (272)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

A gap theorem for $\alpha$-harmonic maps between two-spheres [PDF]

open access: yes, 1914
In this paper we consider approximations introduced by Sacks-Uhlenbeck of the harmonic energy for maps from $S^2$ into $S^2$. We continue the analysis in [6] about limits of $\alpha$-harmonic maps with uniformly bounded energy.
Lamm, Tobias   +2 more
core   +5 more sources

On harmonic mappings [PDF]

open access: yesProceedings of the American Mathematical Society, 1958
1. Suppose that the functions x=x(a, 3), y=y(a, f) define a oneto-one harmonic mapping of the unit disc P in the a, p3-plane (a+i3 ==y) onto a convex domain C in the x, y-plane (x+iy=z). The origin is assumed to be fixed. Introducing two functions F(y) and G(y) which, in r, depend analytically upon the variable y we may write z = Re F(,y) +i Re G(y ...
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

open access: yesFEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

On Linear Combinations of Harmonic Mappings Convex in the Horizontal Direction

open access: yesUniversal Journal of Mathematics and Applications
The process of creating univalent harmonic mappings which are not analytic is not simple or straightforward. One efficient method for constructing desired univalent harmonic maps is by taking the linear combination of two suitable harmonic maps. In this
Elif Yaşar
doaj   +1 more source

Riemannian Polyhedra and Liouville-Type Theorems for Harmonic Maps

open access: yesAnalysis and Geometry in Metric Spaces, 2014
This paper is a study of harmonic maps fromRiemannian polyhedra to locally non-positively curvedgeodesic spaces in the sense of Alexandrov. We prove Liouville-type theorems for subharmonic functionsand harmonic maps under two different assumptions on the
Sinaei Zahra
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

open access: yesAging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel   +4 more
wiley   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt   +5 more
wiley   +1 more source

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