Results 61 to 70 of about 475,497 (278)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Vector Decimation Harmonic Mean-Based Algorithm for Online Acoustic Feedback Active Noise Control

IEEE Access
This research addresses the acoustic feedback and stability performance of Active Noise Control (ANC) systems. The Filtered Cross Least Mean Square (FxLMS) algorithm is one of ANC’s most successful adaptive algorithms for reducing undesired noise.
Suman Turpati, Ajay Roy, Tathababu Addepalli, Mohammed Alkahtani, Abdullatif Hakami, Ahmad Faiz Minai, Abdallah Hammad   +6 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Asymptotically Mean Value Harmonic Functions in Doubling Metric Measure Spaces

Analysis and Geometry in Metric Spaces, 2022
We consider functions with an asymptotic mean value property, known to characterize harmonicity in Riemannian manifolds and in doubling metric measure spaces.
Adamowicz Tomasz, Kijowski Antoni, Soultanis Elefterios   +2 more
doaj   +1 more source

Conservation laws for conformal invariant variational problems

, 2006
We succeed in writing 2-dimensional conformally invariant non-linear elliptic PDE (harmonic map equation, prescribed mean curvature equations...etc) in divergence form. This divergence free quantities generalize to target manifolds without symmetries the
Tristan, Riviere
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Introducing the Harmonic Mean Solving a Tourist’s Problem

Epidemiology, Biostatistics and Public Health, 2022
  This exercise can be given to a group of students with basic knowledge of mathematics and physics at the beginning of a lesson. We can imagine that there will be some students that will solve the exercise using the “common sense” solution recalling ...
Anna Bossi, Anna Zolin
doaj  

Functional means and harmonic functional means [PDF]

Bulletin of the Australian Mathematical Society, 1998
For a continuous function f(t) on (0, ∞) which is strictly monotone and a probability measure μ on [0, 1] we introduce the functional mean and the harmonic functional mean of x > 0 and y > 0 with respect to μ bywhich gives a unified approach to various famous means.Moreover, functional means and harmonic means in n variables are also given and ...
openaire   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source