Results 41 to 50 of about 427 (193)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Labeling Chaos to Learning Harmony: Federated Learning with Noisy Labels

ACM Transactions on Intelligent Systems and Technology
Federated Learning (FL) is a distributed machine learning paradigm that enables learning models from decentralized private datasets where the labeling effort is entrusted to the clients. While most existing FL approaches assume high-quality labels are readily available on users’ devices, in reality, label noise can naturally occur in FL ...
Vasileios Tsouvalas, Aaqib Saeed, Tanir Ozcelebi, Nirvana Meratnia   +3 more
openaire   +2 more sources

Prime Harmonious Labeling of Some New Graphs

IOSR Journal of Mathematics, 2016
In this paper we have introduced prime harmonious labeling of some new graphs. We prove that the graphs Fan fn, Star Sn, Comb graph Pn.Kn , Crown graph Cn . K1,n , Bistar Bn,n , Middle graph M(Pn) and paths are prime harmonious labeling. Keywords: Prime labeling, Harmonious labeling, Prime harmonious labeling, Bistar Bn,n , Middle graph M(Pn).
P. Deepa, S. Uma Maheswari, K. Indirani
openaire   +1 more source

An Example Usage of Graph Theory in Other Scientific Fields: On Graph Labeling, Possibilities and Role of Mind/Consciousness [PDF]

, 2017
This paper provides insights into some aspects of the possibilities and role of mind, consciousness, and their relation to mathematical logic with the application of problem solving in the fields of psychology and graph theory.
Krishnaa, Auparajita
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Edge-sum distinguishing labeling [PDF]

, 2019
We study \emph{edge-sum distinguishing labeling}, a type of labeling recently introduced by Tuza in [Zs. Tuza, \textit{Electronic Notes in Discrete Mathematics} 60, (2017), 61-68] in context of labeling games.
Bok, Jan, Jedličková, Nikola
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source