Results 161 to 170 of about 58,150 (291)

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source

Charting a new course: Recommendations for strategic priorities for the African Medicines Agency. [PDF]

J Public Health Afr
Salami O, Agogo E.
europepmc   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Plasma proteomics of cerebrovascular disease, cognitive decline, and clinical outcomes. [PDF]

Alzheimers Dement
Sim MA, Hilal S, Tromp J, Tan ESJ, Doecke J, Liew OW, Cai VY, Chan SP, Chong EJY, Toh A, Yeow TB, Venketasubramanian N, Barascuk-Michaelsen N, Sim D, Leong GKT, Yeo DPS, Ong HY, Ling LH, Lam C, Lai MKP, Choi H, Richards AM, Chen CLH.   +22 more
europepmc   +1 more source

Multiscale Spatial Fusion Feature‐Driven Characterization of Gastric Cancer Invasive Margins: A Multicenter Cohort Study for Preoperative Accurate Differentiation Between T4a and T4b Subtypes

Advanced Science, EarlyView.
This study develops a multi‐dimensional vision Transformer‐based model, GAVR, to accurately distinguish gastric cancer T4a/b stages preoperatively. Validated across multi‐center cohorts, it achieves excellent performance and significantly improves radiologists’ diagnostic accuracy, offering a promising tool for clinical decision‐making.
Guoliang Zheng, Xiaomiao Chai, Peng Jin, Xin Xin, Yingjie Li, Chun Yang, Jia Wei, Zishuo Yan, Jingyu Zhang, Qianning Zhao, Yingchen Han, Ning Zhang, Fuze Li, Bo Qiao, Huan Wang, Huachuan Zheng, Yan Li, Xin Zhang, Yan Zhao, Wenjun Mao, Jing Zhang   +20 more
wiley   +1 more source

Prospective Physical Activity, Sitting and Sleep consortium (ProPASS): addressing methodological and geographical barriers to inform global public health guidelines, interventions and precision medicine. [PDF]

Br J Sports Med
Stamatakis E, Koemel NA, Mitchell JJ, Atkin AJ, Pulsford R, Chong KH, Rangul V, Blodgett JM, Biswas RK, Celis-Morales CA, Sherar L, Mishra G, McVeigh J, Beauchamp MK, Jannas-Vela S, Petersen CB, Korshøj M, Aadahl M, Jepsen R, Karavirta L, Stenholm S, Sabia S, Richter D, Cistulli PA, Kwok TC, Nemoto Y, Thijssen DHJ, Eijsvogels T, Mork PJ, Alaqil AI, Müller-Riemenschneider F, Micklesfield L, Gallegos-Carrillo K, Severi G, Raina P, Cabanas-Sánchez V, Wanigatunga A, Simonsick EM, Schrack JA, Del Pozo-Cruz J, Bakker EA, Holtermann A, Lee IM, Del Pozo Cruz B, Koster A, Ahmadi MN, Hamer M, ProPASS Collaboration, ProPASS Collaborators.   +48 more
europepmc   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning

Advanced Science, EarlyView.
SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley   +1 more source

Harmonisation of switched memory B cell analysis for improved CVID diagnosis and classification

Frontiers in Immunology
Malicorne Buysse, Jana Neirinck, Ciel De Vriendt, Filomeen Haerynck, Martín Pérez-Andrés, Martín Pérez-Andrés, Alberto Orfao, Alberto Orfao, Mattias Hofmans, Carolien Bonroy, Carolien Bonroy   +10 more
doaj   +1 more source

Preventing Financial Elder Abuse: A Critical Commentary on Harmonisation of Enduring Power of Attorney Laws. [PDF]

Australas J Ageing
Ries N, Tsihlis E, Somes T.
europepmc   +1 more source