Results 51 to 60 of about 873,634 (289)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants

open access: yesPharmaceuticals
RNA interference (RNAi) was originally regarded as a mechanism of eukaryotic post-transcriptional gene regulation mediated by small interfering RNA (siRNA)-induced sequence-specific RNA degradation.
Hara Kang   +6 more
doaj   +1 more source

Introduction: Amelia Jones

open access: yesThe International Journal of Screendance, 2012
No abstract available. This article was originally published by Parallel Press, an imprint of the University of Wisconsin-Madison Libraries, as part of The International Journal of Screendance, Volume 2 (2012), Parallel Press.
Harmony Bench
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Symmetry and symmetry breaking in science and arts

open access: yesProceedings (European Academy of Sciences and Arts), 2022
In this review article, symmetry and symmetry breaking are considered as complementary principles in science and arts. It starts with symmetry and symmetry breaking in early world views of nature and art.
Klaus Mainzer
doaj   +1 more source

Vowel harmony

open access: yes, 2019
Vowel harmony refers to the phonological phenomenon that requires vowels in certain morphological or prosodic domains to agree in specific phonological features. This chapter presents a thorough revision of vowel harmony in southeastern peninsular Spanish, where the loss of some final consonants is compensated by opening the preceding vowel and the lax
Jiménez, Jesús, Lloret, Maria-Rosa
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Levels of use of exclusionary discipline in U.S. public elementary schools: patterns over time and relations with chronic student absenteeism

open access: yesFrontiers in Developmental Psychology
Exclusionary discipline (ExD)—including out-of-school suspensions and expulsions—remains widely used in U.S. public schools despite evidence of its ineffectiveness and disproportionate application.
Richard A. Fabes   +5 more
doaj   +1 more source

Anti-Gravitational Choreographies: Strategies of Mobility in Screendance

open access: yesThe International Journal of Screendance, 2010
No abstract available. This article was originally published by Parallel Press, an imprint of the University of Wisconsin-Madison Libraries, as part of The International Journal of Screendance, Volume 1 (2010), Parallel Press.
Harmony Bench
doaj   +1 more source

Improving music genre classification using automatically induced harmony rules [PDF]

open access: yes, 2010
We present a new genre classification framework using both low-level signal-based features and high-level harmony features. A state-of-the-art statistical genre classifier based on timbral features is extended using a first-order random forest containing
Anglade, A.   +3 more
core   +1 more source

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