Results 51 to 60 of about 178,596 (313)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants

Pharmaceuticals
RNA interference (RNAi) was originally regarded as a mechanism of eukaryotic post-transcriptional gene regulation mediated by small interfering RNA (siRNA)-induced sequence-specific RNA degradation.
Hara Kang, Yun Ji Ga, Jung Won Kim, Chaeyeon Kim, Se-Hwan Son, Chaeeun Gwak, Jung-Yong Yeh   +6 more
doaj   +1 more source

Interrelation of mental "burn out" level and psychological health in athletes with different qualification

Physical Education of Students, 2018
Purpose: to reveal features of psychological health and characteristics of personal development and mental "burn out" of athletes with different qualification.
R.S. Nagovitsyn, A.A. Miroshnichenko, D.R. Merzlyakova, G.Z. Faizullina   +3 more
doaj   +1 more source

Harmony in the NICU [PDF]

Archives of Disease in Childhood - Fetal and Neonatal Edition, 2002
Neonatal intensive care units (NICUs) are stressful places for both parents of babies and health professionals. Most junior doctors in NICUs are competent and find their neonatal experience enjoyable and beneficial to their career. The name neonatal intensive care unit emphasises that the focus is not only INTENSIVE, in terms of trying to cure the ...
T H H G, Koh, T S, Koh
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Síndrome de Capgras secundária a traumatismo crânioencefálico frontal em paciente com transtorno afetivo bipolar tipo II: relato de caso com correlação neuropsiquiátrica

Debates em Psiquiatria
Introdução: As síndromes de identificação delirante são condições neuropsiquiátricas raras caracterizadas pela crença de que indivíduos emocionalmente significativos foram substituídos por sósias idênticos.
Marcos Temistocles Duarte
doaj   +1 more source

Introduction: Amelia Jones

The International Journal of Screendance, 2012
No abstract available. This article was originally published by Parallel Press, an imprint of the University of Wisconsin-Madison Libraries, as part of The International Journal of Screendance, Volume 2 (2012), Parallel Press.
Harmony Bench
doaj   +1 more source

Symmetry and symmetry breaking in science and arts

Proceedings (European Academy of Sciences and Arts), 2022
In this review article, symmetry and symmetry breaking are considered as complementary principles in science and arts. It starts with symmetry and symmetry breaking in early world views of nature and art.
Klaus Mainzer
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source