Results 31 to 40 of about 267,949 (308)

Tunable Applicator for Microneedle‐Based Medical Devices

Advanced Materials Technologies, EarlyView.
This paper presents a simple, low‐cost tunable applicator (TAPP) for microneedle array patches that uses a material‐agnostic controlled‐fracture mechanism to ensure reliable skin penetration and uniform array engagement. The scalable, modular design is compatible with injection molding and 3D printing, can be integrated directly into patches, and is ...
Dan Ilyn, Jihyun (Luna) Hwang, Ian A. Coates, Jacob Dobson, Andy H. Hung, Netra U. Kamat, John R. Tumbleston, Maria T. Dulay, Gunilla B. Jacobson, Joseph M. DeSimone   +9 more
wiley   +1 more source

Data‐Driven Bulldozer Blade Control for Autonomous Terrain Leveling

Advanced Robotics Research, EarlyView.
A simulation‐driven framework for autonomous bulldozer leveling is presented, combining high‐fidelity terramechanics simulation with a neural‐network‐based reduced‐order model. Gradient‐based optimization enables efficient, low‐level blade control that balances leveling quality and operation time.
Harry Zhang, Ganesh Arivoli, Huzaifa Unjhawala, Luning Bakke, Radu Serban, Dan Negrut   +5 more
wiley   +1 more source

The PLANES study: a protocol for a randomised controlled feasibility study of the placental growth factor (PlGF) blood test-informed care versus standard care alone for women with a small for gestational age fetus at or after 32 + 0 weeks’ gestation

Pilot and Feasibility Studies, 2020
Background Stillbirth remains a major concern across the globe and in some high-resource countries, such as the UK; efforts to reduce the rate have achieved only modest reductions.
Joanna Gent, Sian Bullough, Jane Harrold, Richard Jackson, Kerry Woolfall, Lazaros Andronis, Louise Kenny, Christine Cornforth, Alexander E. P. Heazell, Emily Benbow, Zarko Alfirevic, Andrew Sharp   +11 more
doaj   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Immune response against antibiotic-resistant and antibiotic-sensitive staphylococcus aureus in a rat model of implant infection

Scientific Reports
Little is known about the in-vivo dynamics of biofilms associated with medical-device infections and their interplay with systemic inflammation, local immune responses, and tissue healing processes.
Yingfang Fan, Amita Sekar, Madeline McCanne, Jean Yuh, Devika Dutta Kannambadi, Sashank Lekkala, Orhun K. Muratoglu, Ebru Oral   +7 more
doaj   +1 more source

Adhiyajña: Towards a Performance Grammar of the Vedas

Religions, 2019
Recent scholarship has challenged the anachronistic projection of the modern category of the poem onto premodern texts. This article attempts to theorize how one might construct an alternative to modern conceptualizations of “the poem” that ...
Caley Charles Smith
doaj   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Synergistic use of anti-inflammatory ketorolac and gentamicin to target staphylococcal biofilms

Journal of Translational Medicine
Background While antibiotics remain our primary tools against microbial infection, increasing antibiotic resistance (inherent and acquired) is a major detriment to their efficacy.
Amita Sekar, Dmitry Gil, Peyton Tierney, Madeline McCanne, Vikram Daesety, Darina Trendafilova, Orhun K. Muratoglu, Ebru Oral   +7 more
doaj   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Transcendence Un-Extra-Ordinaire: Bringing the Atheistic I Down to Earth

Religions, 2016
I examine challenges to images of a personal god definitive for normatively policed theism (often called “traditional theism”), questioning whether a subject can be conscious of a transcendent being.
Nathan Eric Dickman
doaj   +1 more source