Results 51 to 60 of about 2,572,358 (295)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Synergistic use of anti-inflammatory ketorolac and gentamicin to target staphylococcal biofilms

Journal of Translational Medicine
Background While antibiotics remain our primary tools against microbial infection, increasing antibiotic resistance (inherent and acquired) is a major detriment to their efficacy.
Amita Sekar, Dmitry Gil, Peyton Tierney, Madeline McCanne, Vikram Daesety, Darina Trendafilova, Orhun K. Muratoglu, Ebru Oral   +7 more
doaj   +1 more source

Psi-floor diagrams and a Caporaso-Harris type recursion [PDF]

, 2011
Floor diagrams are combinatorial objects which organize the count of tropical plane curves satisfying point conditions. In this paper we introduce Psi-floor diagrams which count tropical curves satisfying not only point conditions but also conditions ...
A. Gathmann, A. Gathmann, A. Gathmann, A. Gathmann, Andreas Gathmann, E. Brugallé, E. Brugallé, E. Getzler, F. Block, Florian Block, G. Mikhalkin, G. Mikhalkin, H. Markwig, Hannah Markwig, L. Caporaso, M. Gross, M. Kontsevich, M. Kontsevich, R. Pandharipande, R. Stanley, S. Fomin, W. Fulton   +21 more
core   +2 more sources

Phenotypic Diversity and Outcomes in Pediatric NMDA Receptor Encephalitis: A 15‐Year Retrospective Study from the Largest Children's Hospital in the United States

Advanced Science, EarlyView.
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss, Timothy Erickson, Yike Jiang, Varun Kannan, Jonathan M. Yarimi, Kristen S. Fisher, Nikita Shukla, Tim Lotze, Eyal Muscal, Kristy O. Murray   +9 more
wiley   +1 more source

Transcendence Un-Extra-Ordinaire: Bringing the Atheistic I Down to Earth

Religions, 2016
I examine challenges to images of a personal god definitive for normatively policed theism (often called “traditional theism”), questioning whether a subject can be conscious of a transcendent being.
Nathan Eric Dickman
doaj   +1 more source

Harris County Medical Society, Woman\u27s Auxiliary Year Book 1926-1927 [PDF]

, 1926
Partnering with the Texas Medical Association Alliance to improve the health of all Texans, the Harris County Medical Society (HCMS) Alliance was organized in 1919 as the HCMS Woman’s Auxiliary. Current membership consists of the spouses of physicians,
Harris County Medical Society, Woman\u27s Auxiliary
core   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Characterizing interactions of Staphylococcus aureus and Escherichia coli in dual-species implant-associated biofilms

npj Biofilms and Microbiomes
While Staphylococcus aureus is the predominant pathogen in periprosthetic joint infections (PJI), polymicrobial infections involving Gram-negative organisms, such as Escherichia coli, complicate clinical outcomes.
Amita Sekar, Fawaz Ben Malick, Shweta Uma Deepak, Nicoletta Inverardi, Dillon Murugesan, Orhun K. Muratoglu, Ebru Oral   +6 more
doaj   +1 more source

Professor Bryan Harris Remembered: Volez to a Pierce Law Friend [PDF]

, 2004
Bryan Harris, MA (Oxon), passed away recently in his beloved native England, after a brief illness. His wife Mary, two sons and a daughter survive him.
Cavicchi, Jon R.
core   +1 more source

Rational Design of Weakly‐Solvating Molecules for Salt‐In‐Pre‐Ionic‐Liquid Electrolytes for Li Metal Batteries

Advanced Science, EarlyView.
The weakly‐solvating TFMSPyr electrolyte tailors the Li+ solvation structure by suppressing solvent coordination and promoting anion‐dominated solvation. This unique solvation environment induces preferential anion decomposition at electrode interfaces, forming robust inorganic rich S/CEI.
Bishnu P. Thapaliya, Vaidyanathan Sethuraman, Naresh C. Osti, Arvind Ganesan, K. Shawn Reeves, Michael J. Zachman, Albina Y. Borisevich, Harry M. Meyer III, Xiao‐Guang Sun, Eugene Mamontov, Lei Cheng, Sheng Dai   +11 more
wiley   +1 more source