Results 31 to 40 of about 4,205 (287)

ESTABLISHMENT TECHNIQUES FOR TROPICAL LEGUMES IN THE UNDERSTORY OF A EUCALYPTUS PLANTATION

Revista Árvore, 2015
This study evaluated establishment methods for a mixture of herbaceous forage legumes [Centrosema acutifolium, Clitoria ternatea, Pueraria phaseoloides, Stylosanthes Campo Grande (Stylosanthes capitata + S.
Maria Luiza Franceschi Nicodemo, Francisco Humberto Dubbern de Souza, Jose Ricardo Macedo Pezzopane, João Carlos Teixeira Mendes, Waldomiro Barioni Júnior   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Smart Harrowing—Adjusting the Treatment Intensity Based on Machine Vision to Achieve a Uniform Weed Control Selectivity under Heterogeneous Field Conditions

Agronomy, 2020
Harrowing is mostly applied with a constant intensity across the whole field. Heterogeneous field conditions such as variable soil texture, different crop growth stages, variations of the weed infestation level, and weed species composition are usually ...
Michael Spaeth, Jannis Machleb, Gerassimos G. Peteinatos, Marcus Saile, Roland Gerhards   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Optimization of Fuel Consumption for Tractor-tilled Land Area During Harrowing Operation Using Full Factorial Experimental Design

Covenant Journal of Engineering Technology, 2023
This study's aim is to improve the tractor harrowing operation's fuel consumption efficiency to cut operating costs and boost agricultural output. The field trial was conducted at Rivers Institute of Agricultural Research and Training (RIART) Farm ...
Raymond Alex Ekemube, Adekunle Temidayo Atta, Victor, I. Ndirika   +2 more
doaj  

Persisting effects of seed bed preparation and early grazing on plant communities in grassland restoration

Frontiers in Ecology and Evolution, 2023
Semi-natural mountain grasslands are species-rich and provide a wide range of ecosystem services, such as biomass production for livestock grazing and carbon sequestration.
Aure Durbecq, Aure Durbecq, Renaud Jaunatre, Elise Buisson, Cassandra Favale, Nolwenn Maudieu, Armin Bischoff   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source