Results 161 to 170 of about 447,172 (311)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

CREATING AGRIBUSINESS OPPORTUNITIES FOR SMALL SCALE FARMERS IN THABA NCHU BY INTRODUCING WATER HARVESTING TECHNIQUES: A PROFITABILITY AND RISK ANALYSIS

open access: yes
Thaba Nchu is a semi-arid area with low and erratic annual rainfall not exceeding 600mm. Various dryland crops are produced with relatively low yields and high risk of failure.
Baiphethi, Mompati N.   +2 more
core  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling   +16 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan   +9 more
wiley   +1 more source

IMPLICATIONS OF HARVESTING STRATEGIES ON POPULATION AND PROFITABILITY IN FISHERIES

open access: yes
The effects of different harvesting strategies on the mean and variation in size of the fish stock and net revenues are investigated. The strategies analyzed are constant catch, constant effort, and constant escapement.
Steinshamn, Stein Ivar
core  

Designing Rainwater Harvesting Systems Integrating Rainwater into Building Systems

open access: yes, 2014
Water conservation is one of the most effective sustainable design practices, yet few professionals know how to collect and use rainwater effectively. Rainwater Harvesting the first comprehensive book on designing rainwater harvesting systems.
Novak, Celeste Allen   +3 more
core  

Optimal Harvesting in Stream Networks: Maximizing Biomass and Yield. [PDF]

open access: yesBull Math Biol
Nguyen TD   +5 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy